Assessment of endocrine disruption potential of essential oils of culinary herbs and spices involving glucocorticoid, androgen and vitamin D receptors
Food and Function Journal, 10.1039/C7FO02058A
Iveta Bartonkova and Zdenek Dvorak
I wish I knew how strongly the herbs increase the amount of vitamin D getting to cells
I suspect that increasing the Vitamin D dose size provides more benefit than the increasing the herbs
Henry Lahore, founder of Vitamin D Life
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing | Increases |
1) Vitamin D supplement Sun, Ultraviolet -B | Vitamin D in the blood and thus in the cells |
2) Magnesium | Vitamin D in the blood AND in the cells |
3) Omega-3 | Vitamin D in the cells |
4) Resveratrol | Vitamin D Receptor |
5) Intense exercise | Vitamin D Receptor |
6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
7) Quercetin (flavonoid) | Vitamin D Receptor |
8) Zinc is in the VDR | Vitamin D Receptor |
9) Boron | Vitamin D Receptor ?, etc |
10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
11) Progesterone | Vitamin D Receptor |
12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D in the cells |
13) Sulfroaphone and perhaps sulfur | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
If poor Vitamin D Receptor
Ginger on the web
- Boosting Mitochondrial Biogenesis With Ginger GreenMed Info Jan 2020
- https://examine.com/supplements/ginger/
 Download the PDF from Sci-Hub via Vitamin D Life
# = not tested
Essential oils (EOs) of culinary herbs and spices are consumed on common bases. They are multicomponent mixtures of compounds with already demonstrated biological activities. Taking in account regular dietary intake and the chemical composition of EOs, these may be candidates for endocrine disrupting entities. Therefore, we examined the effects of 31 EOs of culinary herbs and spices on the transcriptional activities of glucocorticoid receptor (GR), androgen receptor (AR) and vitamin D receptor (VDR). Using reporter gene assays in stably transfected cell lines, weak anti-androgen and anti-glucocorticoid activity was observed for EO of vanilla and nutmeg, respectively.
Moderate augmentation of calcitriol-dependent VDR activity was caused by EOs of
- ginger,
- thyme,
- coriander and
- lemongrass.
Mixed anti-glucocorticoid and VDR-stimulatory activities were displayed by EOs of turmeric, oregano, dill, caraway, verveine and spearmint.
Remaining 19 EOs were inactive against all receptors under investigation. Analyses of GR, AR and VDR target genes by the means of RT-PCR confirmed VDR-stimulatory, but not anti-glucocorticoid and anti-androgen effects of EOs. In conclusion, while we observed minor effects of several EOs on transcriptional activities of GR, AR and VDR, the toxicological significance is very low. Hence, 31 EOs of culinary herbs and spices may be considered safe, in terms of endocrine disruption involving receptors GR, AR and VDR.
1826 visitors, last modified 17 Feb, 2020, |
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9664 | Essential Oils.pdf | PDF 2018 | admin 08 Apr, 2018 09:34 | 1.42 Mb | 275 |