Daily versus stat vitamin D supplementation during pregnancy; A prospective cohort study
PLoS One. 2020 Apr 16;15(4):e0231590. doi: 10.1371/journal.pone.0231590. eCollection 2020.
Nida Bokharee 1, Yusra Habib Khan 2, Tayyiba Wasim 3, Tauqeer Hussain Mallhi 2, Nasser Hadal Alotaibi 2, Muhammad Shahid Iqbal 4, Kanwal Rehman 5, Abdulaziz Ibrahim Alzarea 2, Aisha Khokhar 1
Tests were made 2 months after start of supplementation
- 2 months is not quite long enough to get full response to 5,000 IU daily
- Response to a single dose will be falling after 2 months, and cannot last long enough for entire pregnancy
- Vitamin D Life speculates that 150,000 IU monthly should be given during pregnancy
- Thus 9 monthly doses vs 270 daily doses
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Injection category listing has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses
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Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:
Dark Skin25 ; Depression 17 ; Diabetes 39 ; Obesity 12 ; Hypertension 35 ; Breathing 29 ; Omega-3 30 ; Vitamin D Receptor 18 - All items in category Infant/Child
606 items - breastfed 887 items as of Jan 2018
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109 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblemReduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Items in both categories Pregnancy and Loading Dose are listed here:
 Download the PDF from Vitamin D Life
Background: Despite favorable climatic conditions, vitamin D deficiency (VDD) is widespread in Pakistan. Current study was aimed to evaluate the prevalence of VDD in Pakistani pregnant women and effectiveness of various regimen of Vitamin D supplementation.
Methodology: This hospital-based prospective cohort study included pregnant women at 12th to 24th weeks of gestation attending Gynae clinic from October 2018 to April 2019. Patients were classified into control and treatment groups (Groups: G1, G2 and G3) according to the dose of vitamin D supplementation. Patients received various regimens of vitamin D including 2000 IU/day (G1), 5000 IU/day (G2) and stat 200000 IU (G3). The levels of vitamin D were measured before and after supplementation. The effectiveness of dosages were compared between and within the groups. Moreover, factors associated with vitamin D sufficiency and insufficiency were ascertained using appropriate statistical methods.
Results: Among 281 pregnant women (mean age: 28.22 ± 4.61 years), VDD was prevalent in 47.3% cases. Vitamin D supplementation caused significant rise in the levels 25(OH)D in treatment groups, while there was no significant difference in control group. The highest mean increment in vitamin D (23.14 ± 11.18 ng/ml) was observed with dose 5000 IU/day followed by doses 200000 IU stat (21.06 ± 13.73 ng/ml) and 2000 IU/day (10.24 ± 5.65 ng/ml). Vitamin D toxicity was observed in one patient who received 200000 IU stat of vitamin D. The frequency of VDD following the supplementation was 5.7%. Education status, duration of sun exposure and use of sunblock was substantially associated with vitamin D sufficiency in the current study.
Conclusion: Our findings underscore the high proportion of VDD among pregnant women in Pakistan. Maternal vitamin D supplementation substantially improved the levels of 25(OH)D. Of three used regimens, the dose of 5000 IU/day is considered safe and equally effective as of 200000 IU stat. Since pregnancy is a time of tremendous growth and physiological changes for mother and her developing fetus with lifelong implications for the child, gestational vitamin D supplementation should be considered to ensure the optimal vitamin D accrual in pregnant women. This study generates the hypothesis that vitamin D supplementation at a dose of 5000 IU/day during pregnancy is superior to the other regimens. However, well-controlled randomized trials are needed to confirm these findings.
PDF shows that one woman had >100 ng of vitamin D at 2 months, but had no medical problems
- “Only one patient attained serum 25(OH)D > 100 ng/ml. However, serum biochemical indices were within the normal range and USG showed no stones in the kidneys. Levene’s test and normality checks were carried out and assumptions met.”
- If they had also measured the vitamin D levels at say 1 month. they most likely would have found >10% with >100 ng of Vitamin D - which is not a problem
There have actually been596 visitors to this page since it was originally made Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020541 visitors, last modified 25 Jul, 2020, This page is in the following categories (# of items in each category)Pregnancy751 Loading dose for Vitamin D 155 Intervention 640 Attached files
ID Name Comment Uploaded Size Downloads 14047 Pregnancy 5,000 and 200,000.jpg admin 17 Jul, 2020 11:03 42.65 Kb 111 14046 Pregnancy - Vitamin D dialy vs stat.pdf PDF 2020 admin 17 Jul, 2020 11:02 923.91 Kb 105 See any problem with this page? Report it (FINALLY WORKS) - All items in category Infant/Child