Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption
Food Chemistry 172 (2015) 155-160 http://dx.doi.org/10.1016Zj.foodchem.2014.09.021 0308-8146
a,b'c, Amelie Dhaussyd, Alain Huertas d,
a INRA, UMR1260 ‘‘Nutrition, Obesity and Risk of Thrombosis'', F-13385 Marseille, France b INSERM, UMR U1062, F-13385 Marseille, France cAix-Marseille Universite, Faculte de Medecine, F-13385 Marseille, France d Lesieur, F-92600 Asnieres-sur-Seine, France
Intestine = mouse, not human
Vitamin K1 not K2
It might be best to take Vitamin K2 at different time than Vitamin D
This study agrees with previous studies: High Vitamin A somewhat blocks Vitamin D
See also Vitamin D Life
- Response to high dose vitamin D is limited by vitamin A - July 2013
- Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015
perhaps due to Vitamin D being blocked - Vitamin A interferes with vitamin D and may be the cause of U shaped relationships – April 2014
- Vitamin A may hinder vitamin D benefits associated with Lung Cancer – July 2013
- Vitamin D3 and K2 combined supplements - perhaps 2016
Taking D and K concurrently might be a bad idea - Vitamin D Cofactors in a nutshell
- Overview Vitamin K and Vitamin D
- Should increase Vitamin K when increasing Vitamin D – RCT Jan 2019
Download the PDF from Vitamin D Life
High dose Vitamin A (black bar) reduces the uptake of Vitamin D
High dose Vitamin D (black bar) reduces in half the uptake of Vitamin K
All of the tall bars are part of the "small" intestine (22 feet in length)
The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites. We then investigated the interactions between FSVs during their uptake by Caco-2 cells. Our data show that vitamin A was mostly absorbed in the mouse proximal intestine, while vitamin D was absorbed in the median intestine, and vitamin E and K in the distal intestine. Significant competitive interactions for uptake were then elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways. Vitamin A also significantly decreased the uptake of the other FSVs but, conversely, its uptake was not impaired by vitamins D and K and even promoted by vitamin E. These results should be taken into account, especially for supplement formulation, to optimise FSV absorption.
35 studies referenced this as of Oct 2020 examples
- Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility - 2015
- Intestinal absorption of vitamin D: a systematic review - 2018
- Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins - 2019
- Vitamin D microencapsulation and fortification: Trends and technologies - 2020 In Vitamin D Life: Fortification with Vitamin D