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Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

See also Vitamin D Life

Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 51 items

20 Most-visited pages in Depression category in Vitamin D Life

Id Page Hits Last modification Creator Categories
7681 Depression 38426
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6247 ALL of the top 10 health problems of women are associated with low vitamin D 26132
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3315 Hypothesis: Some Mental Illness could be treated or prevented with vitamin D 25954
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5777 Suicide associated with low vitamin D 20994
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5764 Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013 17279
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537 Prisoners have very low vitamin D and get TB, influenza, and depression 14423
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1052 Hypothesis - Reduce insomnia with vitamin D 14002
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4658 First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013 12583
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5082 Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014 12176
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5252 Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 11715
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4757 Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013 11019
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4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 10988
29 Apr, 2013 20:21
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3608 Suicide 2X more likely with low vitamin D (in military) – Jan 2013 10802
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7450 MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015 10165
21 Jun, 2018 18:42
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2439 Teens no longer depressed after vitamin D raised to 36 ng – Feb 2012 9986
02 May, 2018 19:17
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5075 Serotonin regulated by Vitamin D – part 1 autism – Feb 2014 8888
14 Dec, 2019 02:54
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6789 Omega-3 prevents PTSD and some mood disorders - Aug 2015 8853
14 Sep, 2019 16:09
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5274 Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014 8775
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317 Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 8592
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838 An Exploratory Study of Postpartum Depression and Vitamin D - May 2010 8464
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Pages listed in BOTH the categories Depression and Omega-3


In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.


Created by admin. Last Modification: Wednesday November 22, 2017 03:00:42 GMT-0000 by admin. (Version 3)
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