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Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020

Re: Preventing a covid-19 pandemic:
Can vitamin D supplementation reduce the spread of COVID-19?
Try first with health care workers and first responders.

01 April 2020, William B. Grant, Research, Sunlight, Nutrition and Health Research Center
PO Box 641603, San Francisco, CA 94164-1603, @wbgrant2

Vitamin D Life

There are better ways to prevent the spread

The best way to reduce the spread of COVID-19 is to massively apply Vitamin D to the hotspots
The increased herd immunity will decrease the the number of individuals to which the virus can spread.
Removing the fuel will make a fire go out.
 
Outbreaks include
Senior home residents
Sailors on Navy Ships
Prisoners
Patients of psych wards
Homeless
Slums
Local Hotspots
 
Should also provide Vitamin D "insurance" to people who contact many others
Hospital staff
Politicians
Celebrities
 
Should also provide Vitamin D "insurance" to essential workers
Grocery clerks
Amazon distribution workers
WalMart employees
Truckers
 
Social distancing and masks just flatten the curve
Vitamin D should actually reduce the total number who will ever get symptoms or go into the hospital


25 most-recent changes to VIRUS pages (Coronavirus)

Id Page Hits Last modification Creator Categories
12067 Governments and other groups are starting to use vitamin D to fight COVID-19 68
15 Nov, 2020 17:24
admin Virus
11580 COVID-19 Coronavirus can most likely be fought by Vitamin D 263897
14 Nov, 2020 18:28
admin Virus
11728 COVID-19 treated by Vitamin D - studies, reports, videos 15614
14 Nov, 2020 17:07
admin Top news
Virus
12065 COVID-19 deaths are proportional to previous interleukin-6 levels, Vitamin D lowers them – Nov 2020 44
14 Nov, 2020 16:40
admin Inflammation
Virus
12064 COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 298
14 Nov, 2020 03:14
admin Virus
12038 Superspreaders appears to have viscous lung fluids – Oct 2020 168
13 Nov, 2020 21:03
admin Breathing
Virus
11974 Dr. Fauci takes 6,000 IU of Vitamin D daily – Sept 2020 5064
13 Nov, 2020 19:05
admin Virus
12057 How to identify and stop the potential superspreaders 76
13 Nov, 2020 18:59
admin Virus
12056 2X fewer COVID-19 deaths observed if infrequent vitamin D (2X more deaths if daily dose) – UK Oct 20, 2020 246
10 Nov, 2020 14:46
admin Virus
12050 Vitamin D fighting COVID-19 meets Bradford Hill Criteria - Nov 2020 216
09 Nov, 2020 18:46
admin Virus
12055 Many problems with Pfizer COVID-19 vaccine – Nov 9, 2020 162
09 Nov, 2020 16:42
admin Virus
12031 Evidence Regarding Vitamin D and Risk of COVID-19 and its Severity - Oct 27, 2020 380
09 Nov, 2020 12:21
admin Virus
12052 Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020 141
09 Nov, 2020 02:16
admin Vitamin D Receptor
Virus
12051 French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020 139
09 Nov, 2020 01:16
admin Loading dose for Vitamin D
Vitamin D in Europe
Virus
12044 Residents of a Nursing Home who choose monthly Vitamin D had 9X fewer COVID-19 deaths – Nov 2, 2020 292
08 Nov, 2020 22:04
admin Virus
11797 Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes – June 3, 2020 884
07 Nov, 2020 12:20
admin Virus
12048 COVID-19 probably fought by 40 ng of Vitamin D - quickly achieved with 200K-400K IU - Oct 28, 2020 231
05 Nov, 2020 17:44
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12047 COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020 103
05 Nov, 2020 11:38
admin Meta-analysis of Vitamin D
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12037 COVID-19 increased risks with low vitamin D: Infection 1.5 X, Hospitalization 1.8 X – meta-analysis Oct 2020 317
05 Nov, 2020 11:26
admin Meta-analysis of Vitamin D
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12046 Chinese COVID-19 study – 80 pct of severe cases had low Vitamin D, all asymptomatic cases had OK Vit D – Oct 13, 2020 234
05 Nov, 2020 09:26
admin Orient
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12039 Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020 317
03 Nov, 2020 12:45
admin Books, videos on Vitamin D
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12023 Zinc (which increases vitamin D in tissues) may both prevent and treat COVID-19 287
03 Nov, 2020 11:32
admin Virus
Zinc
12010 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020 822
03 Nov, 2020 01:42
admin Virus
12043 COVID-19 survivors can have poor health for a long time 94
02 Nov, 2020 18:44
admin Virus
12035 COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020 375
02 Nov, 2020 17:28
admin Breathing
Virus

A single megadose of vitamin D results in good enough levels to fight COVID-19 in 3 days

Standard dosing (10,000 IU/day) takes ~3 months


Dear Editor,

There is reasonable evidence that higher 25-hydroxyvitamin D [25(OH)D] concentrations reduce the risk of respiratory tract infections. A meta-analysis of vitamin D supplementation trials found an inverse relationship between vitamin D supplementation and incidence of acute respiratory tract infections, especially for those with 25(OH)D concentrations below 25 nmol/l [1]. Several mechanisms by which vitamin D reduces risk of respiratory tract infections have been identified. One is that cathelicidens and defensins are induced that have antimicrobial and antiendotoxin properties [2]. Another is that vitamin D reduces the production of pro-inflammatory cytokines and increases production of anti-inflammatory cytokines 2. The innate immune system often goes into overdrive during respiratory tract infections, resulting in the cytokine storm that can damage the lining of the lungs [3]. Serum 25(OH)D concentrations have been found to be inversely correlated with development of acute respiratory distress syndrome [4].

An article tying this and other information together suggests that raising serum 25(OH)D concentrations to 100 – 150 nmol/l should be able to reduce the risk of COVID-19 infection and death [5]. To reach those concentrations rapidly would take large doses of vitamin D for a week or two, followed by several thousand IU/d vitamin D for the duration of the COVID-19 pandemic. Such doses have been found not to have adverse health effects [6]. In addition, vitamin D reduces risk of many chronic diseases such as cancer and diabetes mellitus in secondary analyses of large clinical trials [7], and observational studies have found inverse correlations between serum 25(OH)D concentration and all-cause mortality rate up to 100 nmol/l [8].

No results of clinical trials regarding vitamin D supplementation for prevention or treatment of COVID-19 have been reported. Thus, an important question is whether making a public health announcement that taking enough vitamin D to raise serum 25(OH)D concentrations is a good idea. On the pro side, high-dose vitamin D supplementation and 25(OH)D concentrations have very few adverse side effects [6, 9]. It is also very inexpensive in markets that are not regulated, such as in the United States. Also, high 25(OH)D concentrations are associated with many health benefits [10] (see, also, information at vitaminDWiki.com and Grassrootshealth.net). On the anti side, physicians and health policy makers are reluctant to recommend health interventions that have not been rigorously tested and approved.

In my opinion, supplementation with substantial vitamin D doses is justified based on the enormous health and economic magnitude of the COVID-19 pandemic, the likely benefit in reducing risk of COVID-19 infection incidence and severity, and the preponderance of other health benefits from vitamin D supplementation and higher 25(OH)D concentrations with minimal adverse effects.

In terms of rolling out this recommendation, it is proposed that health care providers and first responders might try it first. Many of them lack adequate personal protective equipment and are contracting COVID-19 as a result. They have the training and motivation to lead the way in evaluating the benefit of vitamin D supplementation to help stem the COVID-19 pandemic. Measuring serum 25(OH)D concentrations at baseline and after supplementing for some time would be useful, especially in terms of evaluating the results in a field study rather than a randomized controlled trial [5].

References

  • 1. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. doi: 10.1136/bmj.i6583
  • 2. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020;12(1):E236. doi: 10.3390/nu12010236
  • 3. Guo XJ, Thomas PG. New fronts emerge in the influenza cytokine storm. Semin Immunopathol 2017;39(5):541-50. doi: 10.1007/s00281-017-0636-y
  • 4. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680
  • 5. Grant WB, Lahore H, McDonnell SL, et al. Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020 doi: 10.20944/preprints202003.0235.v2 [published Online First: 30 March 2020]
  • 6. McCullough PJ, Lehrer DS, Amend J. Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. J Steroid Biochem Mol Biol 2019;189:228-39. doi: 10.1016/j.jsbmb.2018.12.010
  • 7. Grant WB, Boucher BJ. Why Secondary Analyses in Vitamin D Clinical Trials Are Important and How to Improve Vitamin D Clinical Trial Outcome Analyses-A Comment on "Extra-Skeletal Effects of Vitamin D, Nutrients 2019, 11, 1460". Nutrients 2019;11(9) doi: 10.3390/nu11092182
  • 8. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. Am J Public Health 2014;104(8):e43-50. doi: 10.2105/AJPH.2014.302034
  • 9. Grant WB, Karras SN, Bischoff-Ferrari HA, et al. Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects? Dermatoendocrinol 2016;8(1):e1187349. doi: 10.1080/19381980.2016.1187349
  • 10. Charoenngam N, Shirvani A, Holick MF. Vitamin D for skeletal and non-skeletal health: What we should know. J Clin Orthop Trauma 2019;10(6):1082-93. doi: 10.1016/j.jcot.2019.07.004

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