Association of Increased Sun Exposure Over the Life-Course with a Reduced Risk of Juvenile Idiopathic Arthritis.
Photochem Photobiol. 2018 Oct 31. doi: 10.1111/php.13045. [Epub ahead of print]
Chiaroni-Clarke RC1,2, Munro JE2,3,4, Pezic A5, Cobb JE1,2, Akikusa JD3,4, Allen RC3,4, Dwyer T5,6, Ponsonby AL2,5, Ellis JA1,2,7.
- 20 percent less Rheumatoid Arthritis if got lots of sunshine – Feb 2013
- Ultraviolet light (like Vitamin D) is great, especially while pregnant – Aug 2018
- Embrace the Sun – benefits of the sun throughout the day and year – book June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
- Ultraviolet Light in Human Health, Diseases and Environment - book 2017
Items in both categories Rheumatoid Arthritis and Infant-Child are listed here:
- World Arthritis Day - Children who suffer with arthritis are lacking Vitamin D - Oct 2019
- More UVB at 12th week of pregnancy associated with less Juvenile Idiopathic Arthritis – Oct 2018
- Arthritic children have low vitamin D (84 percent of the studies) – May 2018
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Children with Idiopathic arthritis have very low Boron levels – Jan 2016
- 2,000 IU vitamin D recommended for pediatric rheumatology – May 2015
- Juvenile Idiopathic Arthritis is strongly associated with low vitamin D – Aug 2014
- Juvenile Rheumatoid Arthritis associated with low vitamin D, but how low – meta-analysis Jan 2013
UV and D starts with
334 items in UV category- Overview UV and vitamin D
- Vitamin D bulb for use in the home - or perhaps office,
- Sun and UV
- Sun and Vitamin D category has
302 items- UV and Vitamin D calculators, Vitamin D from low-cost UVB lamps
Cutaneous sun exposure is an important determinant of circulating vitamin D. Both sun exposure and vitamin D have been inversely associated with risk of autoimmune disease. In juvenile idiopathic arthritis (JIA), low circulating vitamin D appears common, but disease-related behavioural changes may have influenced sun exposure. We therefore aimed to determine whether pre-disease sun exposure is associated with JIA. Using validated questionnaires, we retrospectively measured sun exposure for 202 Caucasian JIA case-control pairs born in Victoria Australia, matched for birth year and time of recruitment. Measures included maternal sun exposure at 12 weeks of pregnancy, and child sun exposure across the life-course pre-diagnosis. We converted exposure to UVR dose, and looked for case-control differences using logistic regression, adjusting for potential confounders.
Higher cumulative pre-diagnosis UVR exposure was associated with reduced risk of JIA, with a clear dose response relationship (trend p=0.04). UVR exposure at 12 weeks of pregnancy was similarly inversely associated with JIA (trend p=0.011).
Associations were robust to sensitivity analyses for pre-diagnosis behavioural changes, disease duration, and knowledge of the hypothesis.
Our data indicate that lower UVR exposure may increase JIA risk. This may be through decreased circulating vitamin D, but prospective studies are required to confirm this.
More UVB at 12th week of pregnancy associated with less Juvenile Idiopathic Arthritis – Oct 2018 820 visitors, last modified 13 Oct, 2019,
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- Overview UV and vitamin D
- Vitamin D bulb for use in the home - or perhaps office,
- Sun and UV
- Sun and Vitamin D category has
302 items - UV and Vitamin D calculators, Vitamin D from low-cost UVB lamps
Cutaneous sun exposure is an important determinant of circulating vitamin D. Both sun exposure and vitamin D have been inversely associated with risk of autoimmune disease. In juvenile idiopathic arthritis (JIA), low circulating vitamin D appears common, but disease-related behavioural changes may have influenced sun exposure. We therefore aimed to determine whether pre-disease sun exposure is associated with JIA. Using validated questionnaires, we retrospectively measured sun exposure for 202 Caucasian JIA case-control pairs born in Victoria Australia, matched for birth year and time of recruitment. Measures included maternal sun exposure at 12 weeks of pregnancy, and child sun exposure across the life-course pre-diagnosis. We converted exposure to UVR dose, and looked for case-control differences using logistic regression, adjusting for potential confounders.
Higher cumulative pre-diagnosis UVR exposure was associated with reduced risk of JIA, with a clear dose response relationship (trend p=0.04). UVR exposure at 12 weeks of pregnancy was similarly inversely associated with JIA (trend p=0.011).
Associations were robust to sensitivity analyses for pre-diagnosis behavioural changes, disease duration, and knowledge of the hypothesis.
Our data indicate that lower UVR exposure may increase JIA risk. This may be through decreased circulating vitamin D, but prospective studies are required to confirm this.More UVB at 12th week of pregnancy associated with less Juvenile Idiopathic Arthritis – Oct 2018Printer Friendly PDF this page! Follow this page for updates820 visitors, last modified 13 Oct, 2019,