Vitamin D levels at birth and risk of type 1 diabetes in childhood: a case–control study
Acta Diabetologica, May 2015
Francesco Cadario, Silvia Savastio, Veronica Pagliardini, Marco Bagnati, Matteo Vidali, Franco Cerutti, Ivana Rabbone, Franco Fontana, Riccardo Lera, Valeria De Donno, Anna Valori, Gabriella Gruden, Gianni Bona, Graziella Bruno graziella.bruno at unito.it
Aims
To assess whether vitamin D levels at birth were associated with risk of having type 1 diabetes up to 10 years of age and the potential modifier effect of ethnic group.
Methods
The Piedmont Diabetes Registry and the Newborn Screening Regional data were linked to identify cases (n = 67 incident children aged ≤10 years at diabetes onset, 2002–2012) and up to five controls (n = 236) matched for birthday and ethnic group. Cards with neonatal blood spot were used and 25-hydroxyvitamin D(3) assessed with tandem mass spectroscopy.
Results
In conditional logistic regression, OR for unit increment of log vitamin D was 0.78 (95 % CI 0.56–1.10). Vitamin D was significantly lower in migrant than in Italian control newborn babies (p < 0.0001), and interaction between vitamin D and migrant status was statistically significant (p = 0.04). Compared to migrant newborns babies with vitamin D ≥ 2.14 ng/ml, migrants with lower levels had an OR of 14.02 (1.76–111.70), whereas no association was evident in Italians.
Conclusions
Our case–control study within the Piedmont Diabetes Registry showed no association between vitamin D levels at birth and risk of having type 1 diabetes up to 10 years of age, apart from the subgroup of migrant babies, which might have clinical implications if confirmed.
See also Vitamin D Life
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- T1 diabetes OR type1 diabetes in title 26 as of March 2015
Pages listed in BOTH the categories Diabetes and Dark Skin
- Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019
- Blacks die more often than whites of many diseases (they have less vitamin D) – 2012
- Diabetic blacks – 80 percent had low vitamin D (less than 20 ng) a decade before – Sept 2017
- Diabetes is associated with low vitamin D in various races, but not blacks – Sept 2015
- Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- Diabetic glycation control is inversely related to Vitamin D in India – Feb 2015
- Type I diabetes in dark skin children associated with low vitamin D if far from equator – Jan 2015
- Dr. Holick video on vitamin D - March 2013
- African-Americans at high risk of obesity and diabetes - 2011
- Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012
- Hyperglycemia in black veterans is associated with low vitamin D – Nov 2012
- Diabetics with darker skin were more vitamin D deficient – May 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- 97 percent of Native American children have less than 30 ng of vitamin D – Oct 2011
- Diabetic neuropathy and low vitamin D, especially in blacks - July 2011
- Studies linked low vitamin D and dark skin to Obesity, Diabetes, and heart – June 2011
- Not yet certain that vitamin D reduces cardiovascular and diabetes in blacks – Mar 2011
- Diabetes Statistics including more diabetes with darker skin – 2007
- Insulin resistance correlated with low vitamin D levels in Arab Americans – June 2010
- Insulin sensitivity associated with Vit D in A-A April 2010
- Vitamin D deficiency and insulin insensitivity in African Americans - 2010