Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis.
Prev Med. 2013 Sep 10. pii: S0091-7435(13)00318-6. doi: 10.1016/j.ypmed.2013.08.026.
Yin L, Mena JM, Chen T, Schöttker B, Arndt V, Brenner H.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
OBJECTIVE: To conduct a systematic review and meta-analysis of longitudinal studies on the association of 25(OH)D with total cancer incidence and mortality.
METHOD: Relevant longitudinal observational studies were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases. Due to the heterogeneity across studies in categorizing 25(OH)D concentration, all results were recalculated for an increase of 25(OH)D by 50 nmol/L.
RESULTS: In meta-analyses with random effects models, the summary risk ratios and confidence intervals (RRs (95% CI)) for the association of an increase of 25(OH)D by 50 nmol/L with total cancer incidence (5 studies) and mortality (13 studies) were 0.89 (0.81, 0.97) and 0.83 (0.71, 0.96), respectively. In sex-specific analyses no significant association with total cancer incidence was observed among men or women.
A clear inverse association with total cancer mortality was observed among women (0.76 (0.60, 0.98)) but not among men (0.92 (0.65, 1.32)).
Large heterogeneity was observed for studies on total cancer mortality (p<0.01) but not for studies on cancer incidence (p=0.41). No publication bias was found.
CONCLUSION: The meta-analysis suggests a moderate inverse association of 25(OH)D concentration with total cancer incidence and mortality.
See also Vitamin D Life
- Vitamin D still appears to reduce Cancer Mortality – Systematic Review Oct 2012
- Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
- Vitamin D and Cancer Mortality – review Jan 2013
- More US deaths due to cancer than heart if dark skinned – Sept 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 85 percent less risk of death from Breast Cancer when vitamin D levels higher than 30 ng – May 2012
- Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 very similar to 24% reduction with 20 ng