Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients
Disease Markers, Volume 2019, 10 pages, https://doi.org/10.1155/2019/3652894
Jarosław Wajda,1 Maciej Świat,2,3 Aleksander J. Owczarek,4 Aniceta Brzozowska,5 Magdalena Olszanecka-Glinianowicz,5 and Jerzy Chudek6,7
- Stroke recovery was aided by vitamin D and Progesterone (in rats) – Feb 2019
- Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Stroke outcome 6.9 X worse if black and overweight (all three related via low vitamin D) – March 2018
- Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018
- Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Perhaps can prevent stroke by supplementing with Vitamin D
- Overview Stroke and vitamin D
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
Thrombosis
- Blood clotting (Thrombosis) is associated with low Vitamin D (yet again)
- Deep Vein Thrombosis during stroke rehab was 4.7 X more likely if low vitamin D – July 2018
Vitamin D Life: Stroke Meta-analysis
- Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
- Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Cerebrovascular disease 40 percent less likely if high level of vitamin D – meta-analysis Sept 2012
- 50 percent fewer strokes with vitamin D, even though ignored dose size – meta-analysis March 2012
Vitamin D Life: Stroke Mortality
- Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
- Low vitamin D at time of stroke predicts 3 X more likely to die in a month (unless add Vit D) – Dec 2017
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
- Much higher death rate 10 years after TIA – Nov 2011 – vitamin D might help
- Too much and too little Calcium both increase death after strokes – Jan 2011
Download the PDF from Vitamin D Life
Background. Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS.
Methods. Serum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS. Mortality data was obtained from the local registry office.
Results.
- Only three subjects (1.3%) had an optimal 25-OH-D level (30-80 ng/mL),
- 25 (10.4%) had a mildly reduced (insufficient) level,
- 61 (25.4%) had moderate deficiency, and
- 151 (62.9%) had a severe VD deficiency.
20% subjects had secondary hyperparathyroidism. The serum 25-OH-D level was significantly lower than that in 480 matched subjects ( vs. ng/mL).
Of all the patients, 79 (32.9%) died during follow-up observation (44.9 months).
The mortality rates (per year) were 4.81 and 1.89 in a group with and without severe VD deficiency, respectively (incidence rate ratio: 2.52; 95% CI: 1.44–4.68). There was no effect of secondary hyperparathyroidism and iFGF23 levels on mortality rates. Age, ng/mL, and functional status (modified Rankin scale) were significant factors increasing the risk of death in multivariable Cox proportional hazard regression test.
Conclusions. Severe VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status. VD supplementation in IS survivals may be considered due to high prevalence of its deficiency. However, it is uncertain whether it will improve their survival.