Covid-19: More deaths? More lockdown? More suffering?
Vitamin D deficiency causes a 10 times higher death rate in Covid-19 patients according to recent studies.
What we can do to get the Covid-19 pandemic under control and avoid another lockdown
Lorenz Borsche borsche at gmx.de / Dr. Bernd Glauner
 PDF extracted to this page - from authors in Germany
Extraction of tables wad poor - please see PDF
 Original Indonesia preprint Does vitamin D (and C) help with Covid-19 - May 2020
Introduction
The authors see sufficient scientific plausibility that with a good vitamin D level many corona deaths could still be alive today.The studies listed wrt the course of the disease and the death rate in Covid-19 infections dependant on vitamin D level are evident, among others a study with 780 participants. That may be a factor of 12 smaller than a placebo-controlled double-blind study with 10,000 participants. The study is still significant because it shows that infections in groups with deficient vitamin D levels are 10 times more likely to end in death.With a vitamin D supplementation to levels known from nature (East Africa: Massai/Hadza, Central Africa: wild chimpanzees) of 45 ng/ml, there is a good chance that Covid-19 would not have any worse effects than a severe wave of influenza. A lockdown would then be just as unnecessary as the justified fear of our elderly fellow citizens and the risk groups, which imposes an abnormal life on all of us.Quite independently of corona, it has been known and published for many years that vitamin D deficiency promotes the development of pneumonia - technically correct from ARDS (Acute Respiratory Distress Symptom) - as a result of viral infections. In addition, vitamin D stimulates the body's own synthesis of antiviral substances which specifically block the spike protein necessary for the docking mechanism of covid-19 to the receptor protein ACE2. All this is well-researched, published information that clearly shows us that vitamin D deficiency patients are at high risk of getting pneumonia.In today's society, a large part of the population suffers from a massive vitamin D deficiency - especially in winter (see chapter: What else you should know WHO vs. D-A- CH limits).Statistics often assume that blood values of 20ng/ml are sufficient for vitamin D function. But these limits date back to the time when vitamin D was only studied for its effect on bone metabolism. The fact is - and studies in many European countries show this - that depending on the country, 20-40% of people do not even reach this value (20 ng/ml) even in summer. One reason for this is the recommendations for vitamin D substitution. It has been published for years that the official recommendations of 400-800 units of vitamin D per day are based on a calculation error by a factor of 10. Unfortunately, this has still not been included in the official recommendations, as they should be in the range of 5,000 international units per day. Necessary for a stable immune system are blood values of 40- 50ng/ml. But only a few people to reach this level.
The data presented in this article show that up to 90% of deaths could be avoided. This means that the current situation could also be symbolically described as a "vitamin D deficiency pandemic". Unfortunately, in Germany neither the family doctor nor hospitalised patients routinely measure the blood level of vitamin D, even though all relevant organisations, such as the DGE, BfR, RKI and WHO, repeatedly report that our population suffers from a vitamin D deficiency that also causes other health problems.The present study from Indonesia shows exactly the result that must be expected based on the scientific background described above. At vitamin D concentrations below 20 ng/ml, a very large number of patients succumb to the pneumonia triggered by Covid-19, whereas at vitamin D concentrations >30 ng/ml, the majority of patients survive and this with a statistically very good correlation.Large medical studies are very expensive. Someone has to raise the necessary funds in the hope that if the results are positive that tehre will be a revenue. Given the low market price of vitamin D, this simple economic constraint explains why there are relatively few studies on vitamin D. Lorenz Borsche has been trying for a few weeks now to find partners in the medical field in Germany who, with his financial support, carry out purely observational ex-post studies (vitamin D testing of infected persons / course of disease), unfortunately without any success so far. The three studies presented here were initiated by ordinary doctors (MD/GP) and financed from their own resources and with considerable personal commitment(1}. One must therefore not apply the same standard as in large- scale double-blind studies. Nevertheless, the results are so overwhelmingly clear that they should be examined.The rapid increase of vitamin D levels in covid-19 infected patients with vitamin D deficiency (< 30ng/ml), as well as vitamin D supplementation in doctors, nursing staff and risk patients to a healthy blood level of 40-50ng/ml, is - in the authors' view - the only conceivable solution to effectively contain the corona pandemic. One then could most likely allow the SARS-CoV-2 virus to spread and people could survive the infection like a wave of influenza. Apart from the social and economic benefits, this would also be much cmore economic than any other measure and might cost a fraction of what the lockdown has cost and will cost us - in money and in human lives.#000000:__''
The latest studies on Covid-19 and vitamin D
2 May the authors received a publication from Indonesia. Prabowo Raharusuna and his team had examined 780 covid-19 patients for their vitamin D levels. This study is neutral and independent, it was neither sponsored nor are there any other conflicts of interest. depressingly clear!
After correction for age, sex and previous illnesses, the risk of death is 10 times higher for people with vitamin D deficiency. For insufficient vitamin D status still 7 times higher than for sufficient, good vitamin D level.In order to make the evaluation transparent and easy to interpret even for non-scientists, Sadiah Priambada, a statistician in the team, prepared the data in such a way that the three comparison groups with vitamin D levels of <20, 20-30 and >30 ng/ml can be assessed on the basis of an equal age average and an equal number of cases. This more easily readable evaluation leads to practically the same results as the original data, which proves not only the stability of the data, but also the correctness of the previously chosen statistical approach to the calculation of the influencing factors age, sex and previous fluctuations.
1 | Vitamin D < 20 ng/ml (18.2 ± 0.6) | Vitamin D 20-30 ng/ml(26.6 ± 1.4) | Vitamin D > 30 ng/ml(32.1 ± 1.3) | ||||
Overall, N | 60 | 60 | 60 | ||||
Mean age | 61.5 ±4.9 | 61.2 ±3.5 | 61.3 ± 1.6 | ||||
Comorbidity, % | 85.0 | 76.7 | 10.0 | ||||
Death, % | 100.0 | 88.3 | 3.3 | ||||
Active,, % | 0.0 | 11.7 | 96.7 | ||||
The authors could not standardise the comorbidity (pre-existing conditions), too few cases would have remained. One should therefore not compare the percentage of deaths and attribute everything to vitamin D, as this would result in too high a ratio, here about 30:1, instead of 10:1. Every simplification has its limits.The data show that pre-existing conditions have an influence on the course of the infections. It is not possible to say with certainty to what extent the Covid-19 infection or the previous illness is responsible for the occurrence of death. However, the available data suggest that the mortality rate is significantly lower even in the presence of pre-existing conditions when vitamin D levels are sufficient. Whether pre-existing conditions may also be the result of decades of vitamin D deficiency will have to be proven in future studies.The original data (table, 780 cases) is available here as PDF with detailed explanations ofthe data reduction and comments by Sadiah Priambada. There also the contact of the zero line below at approx. 34 ng/ml is explained, what it is based on and what means.
The above graph shows very clearly the dependence of the death rate in hospitalized Covid-19 infected patients on the measured vitamin D concentration in the blood. The data are based on the same data reduction as the above table, but with finer granulation - in 20 groups. The procedure is the same as explained in the PDF above, the same data set was used.There is a very sharp drop in the death rate in the range of blood levels between 27 and 32 ng/ml vitamin D (marked area). At vitamin D levels above 32 ng/ml, the death rate determined in this study is a factor of10 lower than at vitamin D levels below 27 ng/ml.What else you should know (WHO vs. D-A-CH limits):The Indonesians use the international guidelines of the WHO for the vitamin D level: 20 ng/ml is already considered "deficient", i.e. a deficiency, 20-30 is "insufficient", i.e. insufficient, and only more than 30 ng/ml is considered "normal". In Germany, outdated and significantly lower values apply: Above 20 ng/ml is already "normal", 10-20 ng/ml is borderline, and only below 10 ng/ml is a deficiency worthy of treatment established. In most cases, however, this is not treated because far too little tests are carried out. The test has to be paid by the patient himself and is in the order of 30 Euros.German healthy seniors have over 80% "German" normal values, i.e. more than 20 ng/ml. 80% of sick seniors (geriatric patients) on the other hand have insufficient, and half of them values, which even in Germany are classified as deficiency (<10 ng/ml, among others here). From the data of the RKI (Vitamin D status in Germany, p.36, 2016) it can be calculated that 30% of all Germans between 18 and 79 must have far less than 10 ng/ml in the winter quarter (Dec/Feb):
e | |||||||
C | |||||||
RKI_2016 | |||||||
Alter | |||||||
Mangel | |||||||
18-29 Jahre | |||||||
28.4% | |||||||
30 - 44 Jahre | |||||||
32 8% | |||||||
45 - 64 Jahre | |||||||
29.6% | |||||||
65 - 79 Jahre | |||||||
30 0% | |||||||
Schnitt/Jahr | |||||||
30,2% | |||||||
Quartal | |||||||
Mangel | |||||||
J un/Aug | |||||||
8.3% | |||||||
Sep/Nov | |||||||
19,3% | |||||||
Pv1ar/Mai | |||||||
38,4% | |||||||
Dez/Feb | |||||||
52,0% | |||||||
Schnitt/Jahr | |||||||
29,5% |
Abbildung Izeigt. dass der Vitamin-D-Status starken saisonalen Schwankungen unterliegt.Wahrend im Sommer und Herbst 8.3 % bzw. 19.3 % der Erwachsenen einen mangelhaften Vitamin-D-Status aufweisen, sind [es im Fruhling und Winter 38.4 % bzw. 52.0 %. The arithmetical calculation of the dec-Feb values gives an average of 6.81 ng/mlIn fact, however, significantly smaller values are also measured. If a Gauss distribution with values between 2 and 10 ng/ml is taken as a basis, the peak of the curve is only weak 5.9 ng/ml, which would apply to 30% of the population between 18 and 79 in the winter quarter.Since the facts leading to this statement have been known for years, it is hardly understandable that the risks of such a serious deficiency, which are associated with severe health hazards, are not widely discussed.About Prabowo Raharusuna, we received another study on the subject with over 200 subjects, by Mark Alipio, a very young medical doctor from Davao (also, self-financed, neutral and independent).Here too, the results are very clear:
Variables | Overall N (%) | ||||||
Mild | Ordinary | Severe | |||||
Critical | p-value | ||||||
Overall N (%) | 212(100.0) | 49(23.1) | 59 (27.8) | 56 (26.4) | |||
48 (22.6) | |||||||
Serum 25(OH)D, ng/ml | 23.8 | 31.2 ± 1.08 | 27.4 ±2.14 | 21.2 土 112 | 17.1 ±2.39 | <0.001 | |
Vitamin D status | |||||||
Normal | 55 (25.9) | 47 (85.5) | 4(7.3) | 2 (3.6) | |||
2 (3.6) | <0.001 | ||||||
Insufficient | 80(37.7) | 1(1.3) | 35 (43.8) | 23 (28.8) | |||
21 (26.3) | |||||||
Deficient | 77 (36.3) | 1 (1-4) | 20 (26.0) | 31 (40.3) | |||
25 (32.5) |
A study from England also fits the picture:
The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortalityThe researchers around Petre Cristian Ilie have tested the number of Covid-19 deaths per 1 million inhabitants against the vitamin D level in 20 European countries and come to the following conclusion:
The mean vitamin D level in the countries studied (mean 22.4 ng/ml, StDev ±4.24) correlates strictly with the number of Covid-19 infected per million population (mean 295.95, StDev ±298.73, p=0.004) and with mortality (mean 5.96, StDev 15.13,p<0.00001)
The death rates in Spain and Italy are much higher than in Scandinavia. The researchers explain this with the statistically significant higher vitamin D level among the inhabitants of the Nordic countries:The study shows that in older people, the average blood vitamin D level in Spain is 10.4 ng/ml, in Italy, 11.2 ng/ml, while in the Scandinavian countries it is 18 ng/ml.The northerners obviously have the better vitamin D level, although the sun is not as intense there as in the south. This could either be because they are more active outdoors or because they get more vitamin D from food, e.g. fish, or both. Fat sea fish contains a lot of vitamin D. And southerners tend to spend their midday hours in the shade or indoors. Shadow, window glass and a longer way through the atmosphere (morning/evening, autumn/spring) reduce UVB radiation much more than UVA.
Another study from the USA (2016) shows that high supplementation with vitamin D can still help even after the emergency has already occurred, i.e. in patients who need to be ventilated.High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trialIn the study, patients with vitamin D deficiency (<20ng/ml) were divided into three groups: A placebo group, and two groups that were given different doses of vitamin D. The single administration of 250,000 IU of vitamin D was compared with the single administration of 500,000 IU of vitamin D by injection. In addition, the vitamin D levels were increased to 45 and 55 ng/ml, respectively. While the length of stay of the placebo group at the ICU was 36 days, the 250,000 IU group averaged 25 days and the 500,000 IU group averaged 18 days. This is a smooth halving and means that vitamin D is useful not only in prevention but also in acute cases.Another very recent study is by El James Glicio, a retired general practitioner and author from New Delhi:.Vitamin D Level of Mild and Severe Elderly Cases of COVID-19“.Although the study is relatively small, it provides comparable results. The majority (84.6%) of COVID-19 patients with critical course had vitamin D deficiency. Among those under 75 years of age, this was even 100% of critical cases.In the following figure the data are divided according to the international vitamin D level groupings (<20: deficiency, 20-30: insufficient, >30 sufficient/good).One can see very clearly that the severe cases are mostly due to vitamin D deficiency. In the mild cases, patients with good vitamin D levels predominate.Finally a small study in ventilated patients from Iran 2018:Effect of High-Dose Vitamin D on Duration of Mechanical Ventilation in ICU Patients (MirMohammad Miri et al.)
Table 2. Comparison of the me. groups. | m duration of hospitalization, duration of mechanical ventilation and mortality of the patients in two | ||||||
Group | /7-value | ||||||
Control (n = 1$) | |||||||
Intervention (n = 22) | |||||||
Mechanical ventilation (days) | 27.72 ± 22.48 | ||||||
17.63 ± 14 | 0.06 | ||||||
Length of ICU stay (days) | 28.72 ±23.58 | ||||||
19.5 ± 12*2 | 0.06 | ||||||
Mortality (%) | 11 (61.1) | ||||||
8 (3 6.3) | 0.00 | ||||||
Intervention was carried out intramuscularly with 300,000 IU of vitamin D. Instead of 28 days only 18 days mechanical ventilation, instead of 29 only 19 on ICU, instead of 61% deaths only 36%.__''
'What we could do
To sum it all up: If all people, especially the seniors, had a vitamin D level significantly above 30 ng/ml, rather above 40 ng/ml, there would be a high probability that we would not have to fear Covid-19. At 45 ng/ml, as found in native, traditional living peoples near the equator, we should hope to lose practically no one because of Covid-19, unless the comorbidities are so severe that it would have been a matter of days or weeks anyway.From the Indonesian study with 780 participants it follows that the risk of death would only be 1/10 if all of them had vitamin D levels of just over 30 ng/ml. Whether there would have been any deaths at all at 45 ng/ml is difficult to answer; the highest measured value was below 34 ng/ml. Above 33 ng/ml (only women, all without comorbidities) there were no deaths despite hospitalisation.From the Philippine study it follows that people with poor vitamin D levels have an 8 times higher risk of having a "critical" course. So that is the same again. The Iranian "ventilator study" shows a reduction of mortality under artificial respiration by half when vitamin D is administered intramuscularly with 300,000 IU. The American study sees a reduction in the time spent in intensive care units from 36 to 18 days at 500,000 IU.Only every tenth person is still on intensive care, half of which can be saved with high- dose Vitamin D. A lethality rate of 2-4% currently assumed would result in 0.1-0.2% or less, a figure that even a severe flu would reach (2018: 25,000 deaths among perhaps 1520 million infected persons).Apart from this, it is highly plausible that people with comorbidities would also benefit significantly from a better D-level, indeed the entire population as a whole.Moreover, the above studies suggest that a corresponding high-dose intervention would be indicated at the time of hospitalization, not at the time of transfer to the ICU. Which could save even more lives and turn severe courses into mild ones.
And how much does it cost?For a healthy level of more than 45 ng/ml at 70 kg body weight, 5,000 IU vitamin D3 + 200 mcg vitamin-K2, which cost about 7 cents per day, are sufficient. The authors explicitly point out that each vitamin D supplementation must be accompanied by sufficient vitamin K2. This certainly prevents the rise of the calcium level in the blood, which is often seen as a risk for the supply of vitamin DFor people who are not infected with Covid-19, e.g. hospital staff and high-risk patients, corresponding studies show that the vitamin D level can be raised relatively quickly to the "healthy" range if two to three times the amount is administered for two to three weeks (10,000 - 20,000 IU depending on weight). In Covid-19 patients who are hospitalized, the level can be raised immediately to sufficient values with the 500,000 IU syringe mentioned above.From the authors' point of view, this should mean that we no longer need another partial lockdown or special protective measures. The Covid 19 pandemic would continue, but we could safely wait until herd immunity is established if vaccination is not available first. In addition, we would save many billions in costs and avoid social disruption.These assumptions are not only supported by the clinical studies listed, but also by published basic studies: It was investigated how and where vitamin D intervenes in the relevant metabolic pathways. Without going into too much detail, the so-called renin/angiotensin system (RAS) is of particular importance. The misregulation of this system in vitamin D deficiency contributes decisively to the development of ARDS and the triggering of a cytokine storm.A very good summary with quotations from important publications has been compiled by Dr. Renu Mahtani, an American physician of Indian descent (see especially the second half of the lecture). She impressively proves that a sufficient supply of vitamin D is sufficient to keep Covid-19 largely in check. It should be noted that Mrs. Mahtani does not mention the parallel supply of vitamin K2, which is absolutely necessary in the authors' view, when supplementing with vitamin D.Since 20.5.2020, the Red Cross of Poona has been distributing vitamin D3 to senior citizens "in an effort to boost their immunity" according to Dr. Mahtani's protocol.Here is the link to Renu Mahtani's very convincing presentation (in English)__Afterword
It is undisputed that Germany and many other countries have prevented many Covid-19 infections and thus many deaths through their measures. How many more people could have been saved if the information on vitamin D presented here had been known and implemented? Could we perhaps even have avoided the lockdown with all its consequences for our economy and social interaction? The authors have great hopes that this article will help to ensure that vitamin D will in future have the place it deserves in the treatment of Covid-19 infections and that we can at least prevent the "second wave" that is already on everyone's lips about it.Heidelberg/Tubingen, Lorenz Borsche, Dr. Bernd Glauner, May 2020Author's info:Dr. Bernd Glauner studied biochemistry in Tubingen and, after a phase as an independent software developer, was responsible for the development and worldwide distribution of the cell counting device "CASY" for many years - first at 'Scharfe System', then at 'Innovatis' and 'Roche' and finally at 'OMNI Life Science'. In his private life, he has - in addition to his penchant for marathon running - been studying the influence of vitamins on our health for many years.Lorenz Borsche studied mathematics and physics, later sociology and political science. He is a software developer (POS/PPS), but statistics is his real vocation. “Spiegel" once ironically called him a "statistics guru" because of his criticism of PISA. He is the founder of the largest booksellers' cooperative (ebuch eG) with his own nationwide webshop_ "genialokal.de". His most recent book has been published: Sugar: Deadly Temptation. For the vitamin D thesis see also his website: Does vitamin D (& C) help with Covid-19? as well as the latest article of both Dr. B. Glauner / L. Borsche: 7 Cent or lockdown? Ausgewahlte VeroffentHchungen zur Role von Vitamin D bei der Sterblichkeit von Covid-19 Patienten.Selected publications on the role of Vitamin D regarding the mortality of Covid-19 patients.Veroffentlichung 1 - 5 : Klinische Studien und Erkenntnisse
Veroffentlichung 6 - 10 Wissenschafliche Beweise
Publication 1 - 5 : Clinical studies and findings
Publication 5 - 10 Scientific evidence
.Raharusun P, et al. Pattern of Covid-19 Mortality and Vitamin D: An indonesian study. 30. April 2020, SSRN. PreprintAuszug aus dem Abstract / Excerpt from the abstract:The aim was to determine patterns of mortality and associated factors, with a special focus on Vitamin D status.
When controlling for age, sex, and comorbidity, Vitamin D status is strongly associated with COVID-19 mortality outcome of cases.
Link zur Veroffentlichung / Link to the publication:https://papers.ssrn.com/sol3/papers.cfm7abstract id=3585561
Statistische Datenauswertung / Statistical data evaluation Borsche L.:https://borsche.de/res/Indo 1.pdf
.Alipio M. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with coronavirus-2019 (COVID-19). Apr 9, 2020, SSRN. PreprintAuszug aus dem Abstract / Excerpt from the abstract:Vitamin D status is significantly associated with clinical outcomes. A multinomial logistic regression analysis reported that for each standard deviation increase in serum 25(OH)D, the odds of having a mild clinical outcome rather than a severe outcome were approximately 7.94 times (OR=0.126, p<0.001) while interestingly, the odds of having a mild clinical outcome rather than a critical outcome were approximately 19.61 times (OR=0.051, p<0.001).
In conclusion, this study provides substantial information to clinicians and health policymakers. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with COVID-19.
Link zur Veroffentlichung / Link to the publication:https://papers.ssrn.com/sol3/papers.cfm7abstract id=3571484
COVID-19 treated by Vitamin D - studies, reports, videos
Contents as of Nov 9:
- 33 trials, 2 trial results, 30 observations, 11 recommendations, 35 associations, 74 speculations, 26 videos
Top Vitamin D and COVID-19 recent updates
- 2X fewer COVID-19 deaths observed if infrequent vitamin D (2X more deaths if daily dose) – UK Oct 20, 2020
- Vitamin D fighting COVID-19 meets Bradford Hill Criteria - Nov 2020
- French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020
- Chinese COVID-19 study – 80 pct of severe cases had low Vitamin D, all asymptomatic cases had OK Vit D – Oct 13, 2020
- Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020
- COVID-19 increased risks with low vitamin D: Infection 1.5 X, Hospitalization 1.8 X – meta-analysis Oct 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Evidence Regarding Vitamin D and Risk of COVID-19 and its Severity - Oct 27, 2020
- COVID-19 patients who happened to be taking Vitamin D did much better – Oct 27,2020
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- COVID-19 fought by Vitamin D in 43 studies - Oct 15, 2020
- 15 studies indicating that Vitamin D fights COVID-19 - Dr. Grimes Oct 9, 2020
- 32X more likely to have severe-critical COVID-19 in Turkish hospital if Vitamin D deficient – Oct 5, 2020
- {img type="attId" attId="14387" width="250"}
- Vitamin D Cuts SARS-CoV-2 Infection Rate by Half Mercola Sept 28
- 47% lower SARS-CoV-2 positivity rate if > 50 ng vs < 20 ng
- 58% lower risk of testing positive for SARS-CoV-2 if > 30 ng vs < 30 ng
- 2X higher risk of hospitialization if <30 ng
- ICU patients got semi-activated Vitamin D - death rate dropped to 2% from 50%
- Virtually no COVID-19 cases in countries having more than 30 ng of Vitamin D - Sept 17, 2020
- {img type="attId" attId="14336" width="500"}
- Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020
- Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
- {img type="attId" attId="14324" width="500"}
- 14.7 X more likely to die of COVID-19 if less than 12 ng of Vitamin D (185 Germans) – Sept 10, 2020
- {img type="attId" attId="14291" width="450"}
- Low D increases risk of infection. Dr. Fauci Sept 11
- "If you're deficient in vitamin D, that does have an impact on your susceptibility to infection. I would not mind recommending, and I do it myself, taking vitamin D supplements,..." 32 minutes into Instagram interview
- Dr. Fauci takes 6,000 IU of Vitamin D daily – Sept 2020
- {img type="fileId" fileId="3319" width="600" link=https://vitad.org/COVID-19+treated+by+Vitamin+D+-+studies%2C+reports%2C+videos#Observe_-_Less_likey_to_become_infected}
Click on chart for details
- COVID-19 defeated by activated Vitamin D in Spain - pilot RCT Aug 29, 2020
- WHO – Severe COVID-19 mortality reduced by hormones (should consider hormone D too) - Sept 2020
- Vitamin D in Prevention and Treatment of COVID-19 (16 reasons) – Sept 1, 2020
{FONT(size="18")} Search Google Scholar for COVID-19 Vitamin D{FONT} 20,000 publications Oct 10, 2020
Intervention
Intervention Trial Summary Table
{img type="fileId" fileId="3316" width="950"}
- 2X fewer COVID-19 deaths observed if infrequent vitamin D (2X more deaths if daily dose) – UK Oct 20, 2020
- A Clinical Trial, not a Randomized Controled Clinical Trial
- COVID-19 defeated by activated Vitamin D in Spain - pilot RCT Aug 29, 2020
Observe - Less likely to become infected
short URL to this section = https://is.gd/COVID_less
- {img type="fileId" fileId="3319" width="600"}
- 1 Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
- {img type="attId" attId="14324" width="500"}
- 2 COVID-19 increased: 3.5 if Ultra-Orthodox, 2.6X if dark skin (52,000 Israelis) - Sept, 2020
- 3 COVID-19 1.77X less likely if more than 20 ng of vitamin D (489 people) – JAMA Sept 2020
- 1.8 X higher risk if <12 ng vs >30 ng - independent of sex, race
- 4 7X less likely to test COVID-19 positive if had more than 30 ng of Vitamin D (7,804 Israelis) - preprint July 3
- and 20X less likely to be hospitalized for COVID-19
- Peer-reviewed July 23 FREE PDF
- Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study preprint
- COVID-19 antibodies 2.6 X more likely if had symptoms and low vitamin D (UK hospital staff)– Oct 5 2020
- Vitamin D Cuts SARS-CoV-2 Infection Rate by Half Mercola Sept 28
- 47% lower SARS-CoV-2 positivity rate if > 50 ng vs < 20 ng
- 58% lower risk of testing positive for SARS-CoV-2 if > 30 ng vs < 30 ng
- 2X higher risk of hospitialization if <30 ng
- ICU patients got semi-activated Vitamin D - death rate dropped to 2% from 50%
- COVID-19 increased risks with low vitamin D: Infection 1.5 X, Hospitalization 1.8 X – meta-analysis Oct 2020
Observe - Reduced Severity/Death
- Chinese COVID-19 study – 80 pct of severe cases had low Vitamin D, all asymptomatic cases had OK Vit D – Oct 13, 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- COVID-19 patients who happened to be taking Vitamin D did much better – Oct 27,2020
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- 15 studies indicating that Vitamin D fights COVID-19 - Dr. Grimes Oct 9, 2020
- Children infection by COVID-19 had much lower levels than controls Research Gate, Turkey Oct 2020
- 32X more likely to have severe-critical COVID-19 in Turkish hospital if Vitamin D deficient – Oct 5, 2020
- {img type="attId" attId="14387" width="250"}
- Admission to COVID-19 ICU 1.7X more likely to have less than 20 ng of vitamin D – Sept 2020
- Vitamin D levels were NOT associated with COVID-19 severity - Sept 2020
- ALL patients had < 20 ng of vitamin D.
- Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry,
- Hint: need >30 ng to get a benefit doi: 10.3390/nu12092775
- Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020
- COVID-19 3.2X more likely to be severe if vitamin D deficient (80 patients) – Sept 22, 2020
- 14.7 X more likely to die of COVID-19 if less than 12 ng of Vitamin D (185 Germans) – Sept 10, 2020
- Vitamin D associated with less severe COVID-19 (Iran) - Aug 28, 2020
- Less COVID-19 at high altitude due to more Vitamin D or other possible reasons – July 2020
- Far fewer COVID-19 deaths in the summer (Europe, Canada) Aug 21
- Death rates fell as vitamin D levels typically go up in the summer.
- Many charts. 4 other possible reasons for the drop in death rates
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- {img type="attId" attId="14161" width="400"}
- Observations that Vitamin D, Zinc, and Selenium separately reduce COVID-19 – Aug 7, 2020
- Vitamin D Supplementation During the COVID-19 Pandemic Mayo Clinic Letter (Online June 6) Aug 5, FREE 2 page PDF
- "In Slovenia, in view of COVID-19 pandemic, medical doctors were urgently advised by leading experts to supplement vitamin D in high-risk and fragile individuals and in COVID-19 patients"
- Russian Hospital observed 5X more likely to have severe COVID-19 if Vitamin D Deficient – Aug 2020
- Vitamin D Sufficiency Reduced Risk for Morbidity and Mortality in COVID-19 Patients - Holick July 14
- No COID19 deaths in a hospital if >41 ng and <80 years old
- [https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0239799&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plosone%2FPLoSONE+%28PLOS+ONE+-+New+Articles%29|Peer reviewed publication] Sept 25
- "We did observe that 6.3% of the patients who had a blood level of 25(OH)D of at least 40 ng/mL succumbed to the infection compared to 9.7% and 20% who died and had a circulating blood level above and below 30 ng/mL respectively. Thus, a blood level of at least 40 ng/mL may be optimal for vitamin D’s immunomodulatory effect. "
- [https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0239799.s001&type=supplementary|Nice 4 minute video by Dr. Holick] - unfortunately only recommends 1500 - 2000 IU for adults, which will take >6 months to get most people above 16 ng
- {img type="attId" attId="14056" width="500"}
- Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women posted May 29
- Exclusion Criteria: No vitamin D , Vitamin B12 or Zinc supplement use
- Clinical trial Arm1: Observe COVID-19 Deaths and Vitamin D levels in the UK trial completion June 2021
- Arm2: Measure Vitamin D of patients in general practices and see if they get COVID-19 in the next 6 months (prevention)
- Clinical trial observing Vitamin D levels of 500 people in Spain at entry into ICU and recording outcomes hould have been completed July 2020
- Clinical trial to observe vitamin D levels of 100 COVID-19 Turks in hospital should have been completed July 2020
- Bursa City Hospital, NCT04394390
- WHO 3 RCT for Vitamin D and COVID-19 as of May 27 (WHO not responding when asked for details)
- NCT04386044 Investigating the Role of Vitamin D in the Morbidity of COVID-19 Patients 10/05/2020
- NCT04334005 Vitamin D on Prevention and Treatment of COVID-19 29/03/2020
- ChiCTR2000029732 Impact of vitamin D deficiency on prognosis of patients with novel coronavirus pneumonia (COVID-19) 2020-02-10
- Clinical trial to measure Vitamin D status AND vitamin D genes of COVID-19 patients in Portugal Study completion date March 2021
- No intervention, hope they consider genes not noticed by Vit. D tests: such as Vitamin D Receptor, CYP27B1
{FONT(size="18")} Vitamin D Dosing Recommendations for COVID-19{FONT}
- French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020
- COVID-19 probably fought by 40 ng of Vitamin D - quickly achieved with 200K-400K IU - Oct 28, 2020
- A single dose of 300,000 IU of vitamin D should fight COVID-19 for 2 months - Hypothesis - Aug 21, 2020
- Vitamin D recommended for COVID-19 – yet another study – July 17, 2020
- Massive Review of papers on Vitamin D and COVID-19 - July 3, 2020
- {img type="attId" attId="14051" width="800"}
- Portion of image from June 5 video (below)
- {img type="attId" attId="13904" width="500"}
- Parkinson's Disease patients who were taking Vitamin D were 0.56 X less likely to catch COVID-19 - June 2020
- COVID‐19 in Parkinson’s Disease Patients Living in Lombardy, Italy: https://doi.org/10.1002/mds.28176
- {img type="attId" attId="14275" width="800"}
- Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic Metabolism, June 2, FREE PDF, peer-reviewed publication
- "Preventive doses of vitamin D3 of 10,000 IU/day for 4 weeks followed by 5000 IU/day to reach a target 25(OH)D level of 100–150 nmol/L [24], and treatment doses >6000 IU/day in deficient individuals to reach a similar level and reduce disease progression [48], are suggested. ""
- Comment: Strange that the treatment dose is less than the prevention dose. Note treatment dose will take > 3 months to help
- Perhaps they meant the treatment dose to be 60,000 IU, not 6,000 IU
- Perspective: improving vitamin D status in the management of COVID-19 May 22 free PDF
- If low: 50,000 IU twice a week at the diagnosis (100,000 IU total)., then 50,000 IU taken once a week for the 2nd and 3rd weeks.
- Note: Vitamin D Life believes that this dosing is not large enough for prevention, much less treatment
- If low: 50,000 IU twice a week at the diagnosis (100,000 IU total)., then 50,000 IU taken once a week for the 2nd and 3rd weeks.
- COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020
- for people who have not been taking any vitamin D BusinessWorld May 22 - by Dr Renu Mahtani in videos below
- Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
- or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
- Thus 480,000 IU total, No Vitamin D testing needed
{FONT(size="18")}Some people wanted improved immune systems, so took more vitamin D{FONT}
- 2X to 10 X reduction in rate of preemies during COVID-19 in some countries NYT July 19
- No mention about any possible increased Vitamin D sales in Denmark, Ireland, Calgary,
- Sales of vitamin D supplements up 3000% after Public Health England recommendation May 14
- BBC reported a 6X decrease in % people dying of COVID-19 BBC June 16
- {img type="attId" attId="13961" width="600"}
- "Wonder if increased D ==> fewer % of COVID-19 patients ended up dying: 6% ==> 1%. Noted also in Italy
- Alternately, the decreased death rate of COVID-19 patients might be just due to more Vitamin D in the summer
- {img type="attId" attId="13962" width="700"}
- COVID-19 resulted in 3.7X decrease in Irish Very Low Weight Births (Vitamin D) - June 2020 Vitamin D sales had increased by 2500%
- I expect to find many other observations of:
- Fear of COVID-19 ==> Want to improve immune system ==> Take Vitamin D ==> Improved health
- Candidate health concerns for which people have probably have heard about Vitamin D include:
- Pregnancy, Asthma, Multiple Sclerosis, Parkinson's, and Cancer
- I expect to find many other observations of:
{FONT(size="18")}COVID-19 associated with Low Vitamin D{FONT}
- Vitamin D fighting COVID-19 meets Bradford Hill Criteria - Nov 2020
- Magnesium (which increases vitamin D) may fight COVID-19 - Oct 2020
- Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020
- Low serum 25‐hydroxyvitamin D levels in patients hospitalised with COVID‐19 are associated with greater disease severity July 3 FREE PDF
- Has undergone peer review, 200,000 IU Vitamin D occasional dosing, 134 people
- Obesity, walking pace and risk of severe COVID-19: Analysis of UK Biobank preprint July 11
- normal weight slow walkers were 2.5 more likely to get COVID-19
- Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1) July 2020, FREE PDF
- ICU was 2X less likely for COVID-19 hospitalization if Vitamin D more than 20 ng – July 2020
- T1 Diabetic children with low vitamin D have COVID-19 problems (like diabetic adults) - preprint May 15
- COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020
- {img type="attId" attId="13974" width="600"}
- {img type="attId" attId="14057" width="600"}
- Pregnant women admitted to hospital with COVID-19 5X more often than non-pregnant women NYT June 24
- 31% vs 6%. Note: NYT article is confusing. Note: Vitamin D levels drop during pregnancy
- The role of vitamin D in reducing risk of COVID-19: a brief survey of the literature - June 9, 2020 in Vitamin D Life
- Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes – June 3, 2020 in Vitamin D Life
- Founder of Vitamin D Life believes that Causal Modeling will replace many RCTs in the future
- BIG DATA is far faster and lower cost than RCTs while being able to consider far more interactions
- Model A: 16 predictions match observed data; 3 predictions cannot be determined.
- {img type="attId" attId="13906" width="800"}
- Founder of Vitamin D Life believes that Causal Modeling will replace many RCTs in the future
- Obese have major problems with COVID-19 - probably due to lower vitamin D and higher ACE2 June 5, 2020
- Researchers show potential link between vitamin D and coronavirus NBC News Madison Wisconsin May 22
- Reporting on the study from the University in that city - which is below
- Vitamin D for Covid-19? May 12 FREE PDF
- Perspective: improving vitamin D status in the management of COVID-19 European Journal of Clinical Nutrition May 12 FREE PDF
- Avoidance of vitamin D deficiency to slow the COVID-19 pandemic Martin Kohlmeier, BMJ, May 20 FREE PDF
- Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics preprint May 5. updated May 18
- 186 patients. Lower Vitamin D levels associated with worse COVID-19 only for males
- {img type="attId" attId="13801" width="500"}
- Vitamin D levels : all males at same hospital in 2019, males in 2020 with COVID-19
- {img type="attId" attId="13878" width="500"}
- COVID-19 and vitamin D—Is there a link and an opportunity for intervention? Hrvoje Jakova, letter to the editor, May 1, FREE PDF
- [https://www.researchsquare.com/article/rs-30390/v1 |No COVID-19 patient in ICU had >20 ng, 4 had 12.5-20 ng, 13 had < 12.ng ] preprint May 22
- COVID-19 associated with low Vitamin D in more than 20 studies – May 21, 2020 BMJ reply
- Max Minute: How Much Does Vitamin D Help Against COVID-19? CBS News NYC Video May 19
- The Essential Role of Vitamin D in the Biosynthesis of Endogenous Antimicrobial Peptides May Explain Why Deficiency Increases Mortality Risk in COVID-19 Infections preprint May 16 (at least 10,000 IU daily)
- Vitamin D appears to play role in COVID-19 mortality rates Northwestern Univ. May 7
- "Patients with severe deficiency are twice as likely to experience severe complications, including death"
- "...statistical analysis of data from hospitals and clinics across China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the United Kingdom (UK) and the United States."
- There are 2 concurrent pandemics – COVID-19 and Vitamin D deficiency – May 13, 2020
- Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection Irish Medical Journal May 11
- Analysis of 36 COVID-19 patients: Vitamin D status: (nmol) ARDS 27, pneumonia 41;
- and, if <30 nmol. 3.2 X more likely to have intubation
Vitamin D levels are lower in those who test positive for COVID-19 -[doi:10.3390/nu12051359| Nutrients] May 09
- {img type="attId" attId="13798" width="250"}
- [https://articles.mercola.com/sites/articles/archive/2020/05/08/vitamin-d-level-correlated-to-covid19-outcomes.aspx?cid_source=dnl&cid_medium=email&cid_content=art1HL&cid=20200508Z1&et_cid=DM527863&et_rid=867359477 |Vitamin D Level Is Directly Correlated to COVID-19 Outcome] Mercola May 8
- Overview of many studies and video by Ivor Cummins
- [https://www.sciencedaily.com/releases/2020/05/200507131012.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fhealth_medicine%2Fvitamin_d+%28Vitamin+D+News+--+ScienceDaily%29 |Vitamin D linked to low virus death rate in 20 countries in Europe] Science Daily May 7
- [https://doi.org/10.1101/2020.05.01.20087965 |Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes] May 6 preprint
- Excellent extensive use of Causal Influence AI to discover associations.
- I have suspected that Causal Influence could be much better, far lower cost, and faster than the use of RCTs
- [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3586555|Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 deaths] preprint May 7
- "permanent unit increase in UVI is associated with a 2.2 % decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01]
- as well as a 1.9 % decline in the daily growth rates of CFR [p < 0.05]
- 64 countries, 78 days, 6 UVI models
- [https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3593258#.XrE0oF1wSjU.twitter |Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report] May 5
- 176 seniors in S. Asia - published in India
- {img type="attId" attId="13789" width="300"}
- Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020
- COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
- COVID-19 was 19X more likely if low vitamin D (may be invalid data)– April 2020 Philippines
- The raw data has strange gaps in the vitamin D levels
- {img type="attId" attId="13978" width="500"}
- Research Suggests a Link Between Vitamin D Deficiency and COVID-19 Deaths May 5
- Indonesia preprint 13X if vitamin D insufficient,19X for patients who are vitamin D deficient.
- Vitamin D Life has requested but has not yet access to the raw data
- COVID-19 infections associated with very low vitamin D – Turin Italy – March 2020
{FONT(size="18")} Speculation{FONT}
- Evidence Regarding Vitamin D and Risk of COVID-19 and its Severity - Oct 27, 2020
- COVID-19 fought by Vitamin D in 43 studies - Oct 15, 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms Oct 8, behind paywall
- Vitamin D could knock out COVID-19 in 3 months – Dr. Matthews interview Oct 2020
- Studies on Vitamin D and COVID-19 (11 categories) - Sept 20, 2020
- WHO – Severe COVID-19 mortality reduced by hormones (should consider hormone D too) - Sept 2020
- COVID-19 Call to Action – eliminate Vitamin D deficiency – Manson Sept 1, 2020
- Vitamin D in Prevention and Treatment of COVID-19 (16 reasons) – Sept 1, 2020
- AARP features a news item on Vitamin D (and Zinc) and COVID-19 AARP Aug 17
- Nothing new, but it is nice to see Vitamin D being highlighted
- Perhaps the Vitamin D deficiency pandemic caused the COVID-19 pandemic - Aug 17, 2020
- The Covid-19 pandemic is a Vitamin D Deficiency problem and is easy to solve – June 2020
- Mainstream Media Catching on to Vitamin D’s Impact on COVID - Aug 17, 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020 nice chart and table
- Progesterone and ACE2 are possible reasons for fewer female COVID-19 deaths
- {img type="attId" attId="14141" width="250"}
- MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19 in European Journal of Endocrinology Aug 1
- 32 pages, 180 references, FREE PDF
- Vitamin D3 and K2 and their potential contribution to reducing the COVID-19 mortality rate Inter. J. of Infectious Diseases, Aug 5, FREE PDF
- Has a Causal Loop Diagram of Vitamin D3, K2 and the immune system
- Call to Action: Eliminate Vitamin D Deficiency during COVID-19 (7 reasons) – Manson July 23, 2020 in Vitamin D Life
- Vitamin D and Inflammation: Potential Implications for Severity of Covid-19 May 7, PMID: 32603576
- Vitamin D Supplementation: A Potential Approach for Coronavirus/COVID-19 Therapeutics?
- June 23, 2020 FREE PDF, Peer reviewed by Dr. Grant. Includes the following:
- "We demonstrated that a daily oral supplement of 4000 IU of vitamin D during 10 days represented an adequate dose to enhance dengue virus control and reduce the cytokine response, in vitro, suggesting that vitamin D status can, in fact, restrict the viral assault (53, 54)."
- See also Vitamin D Life: Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019
- Experts criticise UK govt. for review of Vitamin D COVID-19 Nutragredients July 2
- "Shouldn't the best available proof be enough when it is better than doing nothing?"
- Nursing homes could reduce risk of COVID-19 with Vitamin D – June 30, 2020
- Hill's Criteria indicates that COVID-19 will be treated by Vitamin D - Annweiler June 8 2020
- Evidence that vitamin D is causally linked to COVID-19 outcomes using
{img type="attId" attId="13965" width="1100"}
- Vitamin D: A cheap yet effective bullet against coronavirus disease-19 – Are we convinced yet?
- June 5, FREE PDF
- How We can fix this pandemic in a month (Vitamin D: 20K IU for 14 days) – June 22, 2020 in Vitamin D Life
- COVID-19 1.9X more likely if Hypocalcemia (which is associated with low vitamin D) June 22, small study, FREE 17 page PDF
- Possible Role of Vitamin D in Covid-19 Infection in Pediatric Population Endocrinol Investigation June 15, FREE PDF
- Covid-19: Public health agencies review whether vitamin D supplements could reduce risk BMJ June 19
- The 2017 BMJ publication that concluded that vitamin D reduced the risk of ARDS was viewed 300,000 times since COVID-19 started.
- An RCT this Winter may be run by the UK to confirm the possibility
- Note: Many other RCTs are already underway - see the top of this section
- Vitamin D and Coronavirus Geriatric Nursing, June 18
- Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship – June 7, 2020 in Vitamin D Life
- Does Vitamin D play a role in the management of Covid-19 in Brazil? April 2020 free PDF
- A strong role, but recommends against high doses such as 10,000 IU - no reason given
- Exploring the Links Between Coronavirus and Vitamin D NYT June 10
- A review of preprints, which does not look at on-line comments about about errors in a few of them.
- Apparently authored by a reporter, not a scientist
- Is Vitamin D One of the Key Elements in COVID-19 Days? June 2020, letter to editor, Turkey
- " Although there is a need for more research related to this subject, we think that supplementing vitamin D as a part of standard nutrition may be somewhat effective in providing clinical benefit"
- El rol de la vitamina D en la infección por SARS-CoV-2 Spanish June FREE PDF
- Is Vitamin D One of the Key Elements in COVID-19 Days? Letter to the editor of The journal of nutrition, health & aging - June 13
- YES, 20 references
- Vitamin D Levels and COVID-19 Susceptibility: Is there any Correlation? June 2 FREE PDF
- 4,000 IU for 2 months should help a lot. No data (yet) to support quickly fighting COVID-19 with loading doses
- Does Vitamin D play a role in the management of Covid-19 in Brazil? June 1, FREE PDF
- Recommends AGAINST 10,000 IU/day
- Supplementing with high doses of vitamin D could represent a promising alternative to prevent or treat COVID-19 infection June 1, peer reviewed ,FREE Spanish PDF
- 10,000 IU daily, 50,000 to 100,000 IU weekly
- Your Vitamin D Level Must Reach 60ng/mL Before the Second Wave Mercola June 1
- Founder of Vitamin D Life believes than 40 ng should be sufficient - based on ~40 studes
- Does vitamin D (and C) help with Covid-19 - May 2020 Germany
- Vitamin D deficiency and COVID-19 pandemic May 29 FREE PDF
- Patrick Zemb a Peter Bergmanb Carlos A.Camargo Jr c, Etienne Cavalier d, Catherine Cormier e, Marie Courbebaisse f, Bruce Hollis g, Salvatore Minisola h Stefan Pilz i, Pawel Pludowsk j, François Schmitt k, Mihnea Zdrenghea l, Jean-ClaudeSouberbielle m"
- Premorbid IL-6 levels may predict mortality from COVID-19 preprint, Morry Silberstein May 29 FREE PDF
- Vitamin D: A simpler alternative to tocilizumab for trial in COVID-19? Medical Hypotheses, Morry Silberstein July 2020 FREE PDF
- "Vitamin D lowers immune cell production of IL-6"
- {img type="attId" attId="13871" width="400"}
- "Vitamin D lowers immune cell production of IL-6"
- Does COVID-19 have a fear of hights? -(or just a fear of the increased VItamin D generated at high altitudes) WP May 31
- Cusco Peru (11,000 feet) - Vitamin D is not mentioned. yet there may be 50% more UVB-generated Vitamin D at that altiude
- "In one peer-reviewed study, published in the journal Respiratory Physiology & Neurobiology, researchers from Australia, Bolivia, Canada and Switzerland looking at epidemiological data from Bolivia, Ecuador and Tibet found populations living above 3,000 meters (9,842 feet) reported significantly lower levels of confirmed infections than their lowland counterparts"
- Reduced COVID-19 in Mexico is associated with higher UV or higher elevation (both of which are associated with higher vitamin D) preprint May 27
- {img type="attId" attId="13865" width="600"}
- {img type="attId" attId="13866" width="600"}
- Vitamin-D and COVID-19: Do Deficient Risk a Poorer Outcome? Lancet May 20
- Reviews many reports and includes the following comment by a researcher of "COVIDENCE UK, a study to investigate how diet and lifestyle factors might influence transmission of SARS-CoV-2, severity of COVID-19 symptoms, speed of recovery, and any long-term effect"
- "Despite his enthusiasm for the study, Martineau is pragmatic: “At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19, but it’s a problem that could be corrected safely and cheaply; there is no downside to speak of, and good reason to think there might be a benefit”.
- Should be cost-effective to use Vitamin D, Vitamin C and Curcumin to fight Covid-19 in India preprint May 22
- Fails to mention dose sizes or frequencies
- U.S. Rep. Glenn Grothman (Wisc.) wants the CDC to investigate if Vitamin D can fight COVID-19 May 22
- Letter: does vitamin D have a potential role against COVID-19 May 20
- {img type="attId" attId="13835" width="450"}
- Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19 Irish Medical Journal, April 2020
- Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment Aug 2020
- both should help fight lung problems. Clinical Trials needed to see to discover dosing and benefits FREE PDF
- Mechanism of inflammatory response in associated comorbidities in COVID-19 PubMed literature Review May 12, free PDF
- "Vitamin D is highlighted as a potential therapeutic target, because in addition to acting on the immune system, it plays an important role in the control of cardiometabolic diseases"
- Vitamin D: A Low-Hanging Fruit in COVID-19? Medscape May 17
- Statements by a dozen doctors, such as Dr. Rosen: "I've been a huge skeptic from the get-go, and loudly criticized the data for doing nothing. I am surprised at myself for saying there might be some effect,"
- DOES VITAMIN D DEFICIENCY REALLY INCREASE RISK OF DEATH FROM COVID-19? Newsweek May 15
- Reviews about 10% of the items on this page
- Which fights COVID-19 more in the long-term - Vitamin D or Ultraviolet light Elemental+ May 13
- Note: Megadoses of Vitamin D can restore the immune system in days, whereas UV takes months
- Vitamin D and SARS-CoV-2 virus (Vitamin D should help) British Medical Journal May 13, 2020
- Unfortunately. the UK consensus is that 400 IU is enough to prevent or treat any health problem, including COVID-19
- The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients preprint April 30
- FoxNews May 7: China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the UK and the US.
- Also reported on in Science Blogs and as The Vitamin That Reduces COVID Risk PSYBLOG May 30
- "Backman said this correlation might help explain the many mysteries surrounding COVID-19, such as why children are less likely to die. Children do not yet have a fully developed acquired immune system, which is the immune system’s second line of defense and more likely to overreact. Children primarily rely on their innate immune system,” Backman said. “This may explain why their mortality rate is lower.”
- "Not only does vitamin D enhance our innate immune systems, it also prevents our immune systems from becoming dangerously overactive"
- Role of vitamin D in pathogenesis and severity of COVID-19 infection preprint April 20
- Includes ACE2 discussion
- {img type="attId" attId="13785" width="500"}
- Perhaps solve the other pandemic: Vitamin D deficiency — to help beat Coronavirus? April 9, Joanneova - Australia 258 comments 10 days later
- Vitamin D reduces viral respiratory infections – editorial April 18, 2020 in Vitamin D Life
- Taiwan seniors have high vitamin D levels, perhaps that reduces the risk of COVID-19 outbreaks von Helden April 18
- Does Vitamin D Protect Us From Viral Infections? April 6
- Croatian, 17 references - probably does protect
- Deficient Vitamin D status might be a severe risk factor for COVID-19 DailyKos April 9
- The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality April 8
- Charts of country levels of vitamin D and COIVD-19 cases and mortality Published May 6
- Chart by von Helden No high death rates if Vitamin D> 30 ng / ml. (Mortality> 0.1 dead / 1000 inhabitants)
- {img type="attId" attId="13800" width="400"}
- COVID-19: Vitamin D deficiency; and, death rates; are both disproportionately higher in elderly Italians, Spanish, Swedish Somali, and African Americans? April 7
- Vitamin D may be a COVID-19 Game-changer - BMJ April 6, 2020
- Vitamins C and D being considered as Coronavirus Treatments - April 7, 2020
- Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020)
- COVID-19 and Vitamin D: Could We Be Missing Something Simple? Children's Health Defence April 9
- COVID-19 prompts awareness of deficiencies of Vitamin D, C and Magnesium - April 6 2020
- Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020
- Vitamin D should prevent COVID-19 (recommended dose takes 3 months to raise levels) - April 2020
- 97 year old woman with hypertension, diabetes, heart problems but with 75 ng of Vitamin D survived COViD-19 von Helden April 10
- Vitamin D supplementation could prevent and treat influenza, CORONAVIRUS, and pneumonia infections - March 2020
{FONT(size="18")} Higher levels of vitamin D result in fewer COVID-19 problems{FONT}
- COVID-19 might be fought by 2 doses of Vitamin D (200,000-300,000 IU each) – Feb 2020 peer-reviewed publication
{FONT(size="18")} VIDEOS and PODCASTS{FONT
- Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020
- UK parliament members starting to be interested in Vitamin D for COVID-19 – Oct 10, 2020 with transcript
- COVID-19 and Vitamin D – 3 minute video - Sept 2020 made by students at low cost, but with high content
- Interview of A Marteneau Aug 2, 36 minutes
- 10X more needed for prevention trial as treatment trial, 400 IU might be useful in the UK
- Chris Masterjohn 33 minute Vitamin D and COVID-19 literature review Aug 14
- " > 30 ng "in some way, shape, or form is associated with lower COVID-19 risk"
- Vitamin D looks very promising - Dr. Cambell July 27, 37 minutes
- High Fructose reduces Vitamin D needed to fight COVID-19 June 12, 2020 video, reviews many studies
- COMING OUT STRONGER FROM LOCKDOWN WITH VITAMIN D: A VITAMIN D MOVEMENT INITIATIVE Renu Mahtani and 3 others 13 minutes, June 5 - see her other video below.
- "It is not an optional supplement, It is a non negotiable cellular necessity" 40 ng minimum
- {img type="attId" attId="13893" width="500"}
- "Worrying about Vitamin D toxicity is like worrying about drowning when you are dying of thirst" Dr. Cannell
- Anecdote: 50,000 IU daily for 10 days given to people who live with person infected by COVID-19 ==> prevented infection
- Rhonda Patrick on Joe Rogan May 17
- Philippines: every standard deviation ==> 8 times more likely chance to have a mild
- Indonesia: only 4% of patients with sufficient vitamin D died.
- Blacks 2X as likely to die from COVID-19 than whites in England
- Daily or weekly vitamin D reduced the risk of acute respiratory infection by more than 50%
- Vitamin D normalizes ACE2 receptor levels in animals
- The Cheapest COVID-19 Therapy in the World May 24
- {img type="attId" attId="13889" width="600"}
- Doctor Mike Hansen - 2 nice videos discussing Vitamin D science and interaction with COVID-19
- Vitamin D3, Vitamin D2 and Calcitriol May 21, 13 minutes Does Vitamin D help with Immunity? May 30 13 minutes
- COVID-19 - Do You Need to Start Getting This Vital Nutrient? Mercola May 31
- Video with Hollis, Wagner, and Baggerly of Vitamin D and COVID-19; a 2nd video of Wagner on the immune system
- Understanding—COVID-19: Actions For Mitigating Risks—Facts & Myths Sunil Wimalawansa, 90 minutes May 27
- Dr. Campbell (has daily COVID-19 videos) COVID-19 and Vitamin D May 9
- Dr. Coimbra: Vitamin D and COVID, 88 minutes in Portuguese May 1
- Click here for transcript in many languages
- COVID-19 and Vitamin D 30 minute updated May 12, excellent, Renu Mahtani
- previous version, taken down by YouTube, had 600,000 views, >2,000 comments
- for people who have not been taking any vitamin D she recommends Business World May 22
- Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
- or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
- Could Vitamin D Help with COVID-19 April 9 India
- Vitamin D against Viral Infections: Antiviral Nutrition 2020 (excerpt 3) by Dr. Alex Vasquez March 6, 8 minutes
- Vitamin D for respiratory infections April 18 Rishi Desai CDC Viral Infections
- Could Vitamin D Help with COVID-19? April 6
- Vitamin D and Immunity, Lots of Evidence April 15 Dr. Campbell
- Vitamin D normalizes the ACE2, which is the attachment point for COVID-19 virus Dr. Patrick Video April 12
- Her video reviews about a dozen publications. Her description of the importance of vitamin D starts at 24:52
- Many videos by Sunil Wimalawansa April 12-- - , 5-10 minutes each
- He is starting a Randomized Controlled Trial in Sri Lanka for COVID-19 treatment by Vitamin D - not described in the videos
- 20: Vitamin D & COVID-19
- 21: How does vitamin D reduce COVID-19 infection?
- 22: What is ACE2 receptor, through which COVID-19 enters cells
- 23: How does COVID-19 kill us?
- 26: How does vitamin D reduce COVID-19 infection
- 44: What have we learned during the past 2 weeks on COVID-19?
- 45: How vitamin D help to attenuate COVID-19?
- 48: Herd immunity and the importance of testing
- 53 Reducing the severity of COVID-19 with vitamin D adequacy
- 54: Tropical countries, warm weathwer, and lower deaths due to COVID-19
- See also Video May 27 90 minute
- Dr. Eric Berg DC April 5 - one of his many vitamin D videos
- Take 100,000 IU of vitamin D, and again 3 months later to prevent COVID-19 Dr. Anderson March 22
{FONT(size="18")} Groups which actively ignore Vitamin D possibility{FONT}
- The Wellcome-Gates COVID-19 Accelerator initiative expressly prohibits funding for Vitamins.
Why/How Vitamin D both treats and prevents virus
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- Coronaviruses attach to cells via ACE2, Vitamin D might reduce ACE2
- All previous Coronarvirus have been treated by Vitamin D
- Most enveloped virus are treated by Vitamin D
- Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis, Ebola) – March 2011
- Also: cytomegalovirus, retrovirus-like HIV, Dengue, Yellow fever. Measles, Mumps, smallpox
- The interplay between vitamin D and viral infections – Jan 2019
- Influenza virus might be prevented and treated by Vitamin D, if no vaccination – Aug 2018
- Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015
- Influenza of 1918 and vitamin D - July 2010 -an H1N1 that was strongly associated with low vitamin D
- Dengue fever - 8X higher risk for getting worse if low vitamin D – Sept 2017
- Immune system is fortified by Vitamin D (other supplements help too)
- Colds and flu prevented and treated by Vitamin D - many studies
Short URL for this section = https://is.gd/COVItaminD