Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial
International Journal of Chronic Obstructive Pulmonary Disease Volume 2019:14 Pages 1495—1501, https://doi.org/10.2147/COPD.S207400
- COPD 2.8 times more likely to be severe if low vitamin D – meta-analysis Oct 2016
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- COPD severity is associated with Vitamin D deficiency – meta-analyses 2015, 2019
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- COPD trial to use 80,000 IU of vitamin D weekly – RCT 2021
COPD Overview has the following
- COPD = Chronic Obstructive Pulmonary Disease Wikipedia
- COPD has dramatically risen to become the 3rd leading cause of death
- COPD is 2 times as likely if you have low vitamin D
- COPD worsens 3X faster if < 0 ng of Vitamin D
- COPD attack is 30 times more likely if low vitamin D
- COPD can be effectively treated by Vitamin D
- using 50,000 IU weekly or 100,000 IU monthly
- COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019
- COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019
- Worse breathing with COPD is related to lower Vitamin D – June 2018
- COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
- COPD and Vitamin D, concise (46 page) review – Dec 2016
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT
AND includes the following sections
50,000 IU weekly - 6X more likely to improve breathing - 2014
50,000 IU helped COPD in many ways - Jan 2015
COPD has become the 3rd largest global cause of disability: ages 50-69
Loading Dose
- Overview Loading of vitamin D
- Loading may be done as quickly as a single day, to as slowly as 3 months.
- It appears that spreading the loading dose over 4-20 days is a good compromise
A CAT (COPD Assesment Test) score - from the web (not the one they used)
Download the PDF from Vitamin D Life
COPD Assesment Test improved signifiantly after 2 month loading dose
and doubled that improvement after maintenance dosing of 6 months
Ali Alavi Foumani,1 Mojtaba Mehrdad,1,2 Alireza Jafarinezhad,1 Khadijeh Nokani,3 Alireza Jafari1
- 1 Inflammatory Lung Diseases Research Center, Dept of Internal Medicine, Razi Hospital, School of Medicine, Guilan U. of Medical Sciences, Rasht, Iran;
- 2 Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran;
- 3 Student Research Committee, Department of Internal Medicine, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D3 once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.