Lower maternal serum 25(OH) D in first trimester associated with higher autism risk in Chinese offspring
Journal of Psychosomatic Research, Volume 89, October 2016, Pages 98–101, http://dx.doi.org/10.1016/j.jpsychores.2016.08.013
Jianzhang Chen a, b, chanjz at 126.com, Kuolin Xin b, Junjie Wei c, Kangli Zhang b, , , Huajun Xiao d
Highlights
- Vitamin D deficiency was hypothesized to play role in ASD.
- Maternal 25(OH) D in autistic group lower than in typically-developing group
- Maternal 25(OH) D concentrations were associated with risk of developing autism.
- This is an opportunity for prenatal intervention to reduce the risk for autism.
Objective
The aim of this study was to examine the association between maternal serum vitamin D status in first trimester and risk of ASD at age 3–7 years in the offspring.
Methods
Using a case-control design, 68 children diagnosed with ASD and 68 sex and age matched typically-developing children were included. Archived maternal blood samples from the first trimester of pregnancy (11–13 weeks gestational age) were identified for those participants. Maternal serum levels of 25 hydroxyvitamin D3 [25(OH) D], unmetabolized folic acid (FA), vitamin B12, homocysteine (HCY) and High Sensitivity C Reactive protein (CRP) were measured from those samples. We examined the associations between those factors in pregnancy and diagnosis of ASD with logistic regression using SPSS.
Results
Mothers in autistic group had significantly lower maternal serum levels of 25(OH) D than in typically-developing group [19.2(IQR: 15.8–22.9) ng/ml vs. 24.3 (19.3–27.3) ng/ml, P < 0.001], with 55.9% and 29.4% being vitamin D deficient, respectively (P < 0.001). Levels of 25(OH) D increased with decreasing severity of ASD as defined by the CARS score (r = - 0.302, P < 0.001). Maternal first trimester serum levels of 25(OH) D in the lower 3 quartiles (quartile 1, 2, 3) (compared to the highest quartile) was associated with increased odds of ASD diagnosis in offspring [OR (95% CI) Q1: 1.36(0.84–2.58, P = 0.25); Q2: 2.68(1.44–4.29, P = 0.006); Q3:3.99 (2.58–7.12, P < 0.001)].
Conclusions
Lower first trimester maternal serum levels of 25(OH) D were associated with increased risk of developing autism in offspring. If these findings are confirmed, this may present an opportunity for prenatal intervention to reduce the risk for ASD.
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See also Vitamin D Life
- Autism associated with low vitamin D during pregnancy – Nov 2016
- Autistic measure 5X more likely if low vitamin D in second trimester – Oct 2012
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Autism is associated with low vitamin D – meta-analysis Oct 2015
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
- Autism 17 times more likely with excessive Folic Acid and B-12 (now added to bread) – May 2016
Autism category in Vitamin D Life starts with
Autism category has - see also Overview Autism and vitamin D, Autoimmune , Cognitive, ADHD
Interesting Autistic studies
Autism associated with low Vitamin D
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Premature birth 2.5X more likely if mother had low vitamin D and was having twins – July 2013
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Having twins takes more vitamin D - May 2011
Autism treated by Vitamin D
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism reduced by vitamins before and during pregnancy
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D to the tissues)
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
Vaccines increase the risk
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
- Off topic: CDC deleted a 3X increase in black male autism due to vaccination – whistle blowing Aug 2014
Dr. Cannell on Autism and Vitamin D
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
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