Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D
Am J Public Health. Published online ahead of print June 12, 2014: e1–e8. doi:10.2105/AJPH.2014.302034
Cedric F. Garland, DrPH, June Jiwon Kim, BS, Sharif Burgette Mohr, PhD, MPH, Edward Doerr Gorham, PhD, MPH, William B. Grant, PhD, Edward L. Giovannucci, MD, ScD, Leo Baggerly, PhD, Heather Hofflich, DO, Joe Wesley Ramsdell, MD, Kenneth Zeng, BS, and Robert P. Heaney, MD
Cedric F. Garland and Edward D. Gorham are with the Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla.
June J. Kim, Sharif B. Mohr, and Kenneth Zeng are with Leidos Biomedical Research, Inc., San Diego.
William B. Grant is with Sunlight and Nutrition Research Center, San Francisco, CA.
Edward L. Giovannucci is with departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA.
Leo Baggerly is with Research Department, GrassrootsHealth, San Diego.
Heather Hofflich and Joe W. Ramsdell are with Internal Medicine Group, Department of Medicine, University of California San Diego.
Robert P. Heaney is with Department of Medicine, Creighton University, Omaha, NE.
Correspondence should be sent to Dr. Cedric F. Garland, Professor, Department of Family and Preventive Medicine, Division of Epidemiology 0620, University of California San Diego, La Jolla, CA 92093-0620 (e-mail: cgarland at ucsd.edu).
ABSTRACT
We examined the relationship between serum 25-hydroxyvitamin D (25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data.
The hazard ratio for all-cause mortality comparing the lowest (0–9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001). Serum 25(OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01).
Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
Download the PDF from Vitamin D Life
See also Vitamin D Life
- Less likely to die if have enough vitamin D - Meta-analysis June 2014 and month, different authors
- 6 percent less likely to die by taking just a little vitamin D for 3 plus years – RCT Dec 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Dr. Grant on vitamin D and mortality in Vitamin D Life Dr. Grant is one of the authors of the study on this page
- Death rate 2X higher at age 60 if low vitamin D - 180,000 in Israel May 2012
very similar to the conclusion of the study on this page - see following chart