While the assertion that the level of 1,25(OH)2 D can not be reliably estimated by serum 25(OH)D has merit, the thesis has several weaknesses in these assumptions made:
Low serum 25(OH)D is also found in healthy persons exposed to adequate sunlight
Despite increased vitamin D supplementation inflammatory diseases are increasing
Assessment of both metabolites often reveals elevated 1,25(OH)2D
Therefore, it would be prudent to use the IOM vitamin D deficiency guideline in the clinical setting, for clinical studies and when evaluating research results.
Bogh et al. 22 measured the baseline serum 25(OH)D and total cholesterol levels of 182 fair-skinned and dark-skinned subjects; and studied the effect of UV radiation on their serum 25(OH)D levels. They found the amount of serum 25(OH)D produced was determined by the amount of cholesterol in the skin, not on skin pigmentation.
However, despite the up to fourfold reduction in vitamin D3 production in a 70-year-old compared to a 20-year-old, the skin has such a high capacity to make vitamin D3 that elders exposed to sunlight will produce an adequate amount of vitamin D3 to satisfy their vitamin D requirement
Acceptance of these vitamin D myths regarding photosynthesis prevents consideration of the alternate hypothesis
in the absence of disease, low 25(OH)D is normal
Anyone with a good knowledge of the literature should be able to criticize any of these statements.
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While the assertion that the level of 1,25(OH)2 D can not be reliably estimated by serum 25(OH)D has merit, the thesis has several weaknesses in these assumptions made:
Low serum 25(OH)D is also found in healthy persons exposed to adequate sunlight
Despite increased vitamin D supplementation inflammatory diseases are increasing
Assessment of both metabolites often reveals elevated 1,25(OH)2D
Therefore, it would be prudent to use the IOM vitamin D deficiency guideline in the clinical setting, for clinical studies and when evaluating research results.
Bogh et al. 22 measured the baseline serum 25(OH)D and total cholesterol levels of 182 fair-skinned and dark-skinned subjects; and studied the effect of UV radiation on their serum 25(OH)D levels. They found the amount of serum 25(OH)D produced was determined by the amount of cholesterol in the skin, not on skin pigmentation.
However, despite the up to fourfold reduction in vitamin D3 production in a 70-year-old compared to a 20-year-old, the skin has such a high capacity to make vitamin D3 that elders exposed to sunlight will produce an adequate amount of vitamin D3 to satisfy their vitamin D requirement
Acceptance of these vitamin D myths regarding photosynthesis prevents consideration of the alternate hypothesis
in the absence of disease, low 25(OH)D is normal
Anyone with a good knowledge of the literature should be able to criticize any of these statements.