Vitamin D reduces BMI and waist circumference – umbrella meta-analysis

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

Front Nutr. 2022 Sep 7;9:980749.doi: 10.3389/fnut.2022.980749

Vali Musazadeh 1 2 , Meysam Zarezadeh 1 3 , Faezeh Ghalichi 1 3 , Fateme Hamedi Kalajahi 1 3 , Zohreh Ghoreishi 3

Despite the growing evidence from meta-analyses on vitamin D's anti-obesity properties, their results are controversial. The current umbrella review was performed to assess the available evidence and provide a conclusive explanation in this regard. The international databases PubMed, Scopus, Embase, Web of Science and Google Scholar were systematically searched till March, 2022. A random-effects model was used to run the meta-analysis. All meta-analyses that examined the effect of vitamin D supplementation on BW, BMI, WC, and fat mass were included.

Findings of 14 meta-analyses revealed that vitamin D supplementation reduced

• body mass index (BMI) (ES: -0.11 kg/m2; 95% CI: -0.18, -0.05, p?0.001; I 2 = 61.0%, p < 0.001), and

• waist circumference (WC) (ES = -0.79 cm; 95% CI: -1.20, -0.37; p < 0.001; I 2 = 46.5%, p = 0.096)

in comparison to control group.

However, the effects of vitamin D on

• body weight (ES = -0.16 kg, 95% CI: -0.36, 0.04; p = 0.125; I 2 = 57.0%, p = 0.017), and

• fat mass (ES: 0.02, 95

% CI: -0.20, 0.24, p = 0.868; I 2 = 0.0%, p = 0.531)

were not considerable.

Vitamin D supplementation significantly improved levels of obesity indices such as BMI, and WC.

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