Vitamin D genes – Review
Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research
Nutrients 2022, 14(13), 2735; https://doi.org/10.3390/nu14132735
by Rasha Shraim 1,2,3ORCID,Conor MacDonnchadha 1,2ORCID,Lauren Vrbanic 1,2,Ross McManus 2,† andLina Zgaga 1,*,†
1 Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, D24 DH74 Dublin, Ireland
2 Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, D08 W9RT Dublin, Ireland
3 The SFI Centre for Research Training in Genomics Data Sciences, National University of Ireland Galway, H91 CF50 Galway, Ireland
Vitamin D is essential for good health. Dermal vitamin D production is dependent on environmental factors such as season and latitude, and personal factors such as time spent outdoors and genetics. Varying heritability of vitamin D status by season has been reported, suggesting that gene-environment interactions (GxE) may play a key role. Thus, understanding GxE might significantly improve our understanding of determinants of vitamin D status. The objective of this review was to survey the existing methods in GxE on vitamin D studies and report on GxE effect estimates. We searched the Embase, Medline (Ovid), and Web of Science (Core Collection) databases. We included only primary research that reported on GxE effects on vitamin D status using 25-hydroxyvitamin D as a biomarker.
Sun exposure was the only environmental exposure identified in these studies. The quality assessment followed the Newcastle–Ottawa Scale for cohort studies. Seven studies were included in the final narrative synthesis. We evaluate the limitations and findings of the available GxE in vitamin D research and provide recommendations for future GxE research. The systematic review was registered on PROSPERO (CRD42021238081).
📄 Download the PDF from Vitamin D Life
Vitamin D Life - Genetics category contains
{include}
Vitamin D Life - Some diseases reduce vitamin D getting to blood or cells
{include}
Vitamin D Life - CYP27B1 category contains
{include}
--=
Vitamin D Life - Cancers might alter CYP24A1 gene
{include}
Vitamin D Life - Vitamin D Binding Protein category listing has items
{include}
Vitamin D Life - Health problems associated with poor Vitamin D Binding Protein (GC)
{include}
Vitamin D Life - The Vitamin D Receptor is associated with many health problems
{include}
Vitamin D Life - Vitamin D Receptor category contains
{include}
Diseases associated with a poor Vitamin D Receptor
{include}
Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
{include}