Vitamin D blocks Vitamins K1, Vitamin A – 2015

Created January 2017

Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption

Food Chemistry 172 (2015) 155-160 http://dx.doi.org/10.1016Zj.foodchem.2014.09.0210308-8146

a,b'c, Amelie Dhaussyd, Alain Huertas d,

a INRA, UMR1260 ‘‘Nutrition, Obesity and Risk of Thrombosis'', F-13385 Marseille, France b INSERM, UMR U1062, F-13385 Marseille, France cAix-Marseille Universite, Faculte de Medecine, F-13385 Marseille, France d Lesieur, F-92600 Asnieres-sur-Seine, France

Intestine = mouse, not human, fpr Vitamin K1 not K2Update July 2024: K2 does not block D3 in humany Perplexity AIThis study agrees with previous studies: High Vitamin A somewhat blocks Vitamin D 1. See also Vitamin D Life* Response to high dose vitamin D is limited by vitamin A - July 2013* Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015 * perhaps due to Vitamin D being blocked* Vitamin A interferes with vitamin D and may be the cause of U shaped relationships – April 2014* Vitamin A may hinder vitamin D benefits associated with Lung Cancer – July 2013* Vitamin D3 and K2 combined supplements - perhaps 2016* Taking D and K concurrently might be a bad idea* Vitamin D Cofactors in a nutshell* Overview Vitamin K and Vitamin D* Should increase Vitamin K when increasing Vitamin D – RCT Jan 2019

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High dose Vitamin A (black bar) reduces the uptake of Vitamin D

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High dose Vitamin D (black bar) reduces by half the uptake of Vitamin K

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All of the tall bars are part of the "small" intestine (22 feet in length)

The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites. We then investigated the interactions between FSVs during their uptake by Caco-2 cells. Our data show that vitamin A was mostly absorbed in the mouse proximal intestine, while vitamin D was absorbed in the median intestine, and vitamin E and K in the distal intestine. Significant competitive interactions for uptake were then elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways. Vitamin A also significantly decreased the uptake of the other FSVs but, conversely, its uptake was not impaired by vitamins D and K and even promoted by vitamin E. These results should be taken into account, especially for supplement formulation, to optimise FSV absorption.

211 studies cited this as of July 2024

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  • Impact of pulses, starches and meat on vitamin D and K postprandial responses in mice - Feb 2023 https://doi.org/10.1016/j.foodchem.2022.133922

    • Chickpeas and meat are associated with decreased vitamin K compared to potatoes (40%? 90%?)

  • Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility - 2015

  • Intestinal absorption of vitamin D: a systematic review - 2018

  • Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins - 2019

  • Vitamin D microencapsulation and fortification: Trends and technologies - 2020  In Vitamin D Life: Fortification with Vitamin D

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Tags: Vitamin A Vitamin K