The earlier the better- preconception vitamin D

The earlier the better: preconception vitamin D and protection against pregnancy loss.

Lancet Diabetes Endocrinol. 2018 Jun 5. pii: S2213-8587(18)30178-5. doi: 10.1016/S2213-8587(18)30178-5. [Epub ahead of print]

Hewison M, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre for Endocrinology, Diabetes and Metabolism, U. of Birmingham and Birmingham Health Partners, Birmingham, B15 2TT, UK [email protected].

PDF is available free at Sci-Hub

PMID: 29884467 DOI: 10.1016/S2213-8587(18)30178-5

This is an editorial comments on

Mumford SL, Garbose RA, Kim K, et al.

Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 2018; online May 30. In Vitamin D Life Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018

Preconception supplementation appears to reduce problems with

Becoming pregnant

Miscarriage

First trimester supplementation reduces problems with

Infant teeth

Autism

Asthma

Healthy pregnancies need lots of vitamin D has the following summary

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Fertility and Sperm category contains the following summary

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Fertility

• Having a good level of vitamin D before conception helps – Aug 2018

• Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT Nov 2017

• Poor fertility in both women and men associated with low vitamin D – review Feb 2018

• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015

• Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017

  See also

• Ensure a healthy pregnancy and baby - take Vitamin D before conception

Some related publications by M Hewison

• Vitamin D, the placenta and early pregnancy: effects on trophoblast function Feb 2018 PDF online

• Dysregulation of maternal and placental vitamin D metabolism in preeclampsia Feb 2017 PDF online

• Search Vitamin D Life for HEWISON 905 items as of Aug 2018

• Decidua immunity and Vitamin D – dissertation July 2018 Hewison was thesis advisor