Taking Vitamin D just before and after surgery helps (open-heart in this case) – RCT

Created February 2021

Vitamin D supplementation protects against reductions in plasma 25-hydroxyvitamin D induced by open-heart surgery: Assess-d trial

Physiol Rep. 2021 Feb;9(3):e14747. doi: 10.14814/phy2.14747.

Tyler Barker 1 2, Heidi T May 3, John R Doty 3 4, Donald L Lappe 3 4, Kirk U Knowlton 3 4, John Carlquist 3, Kristin Konery 3, Shannon Inglet 3, Ben Chisum 3, Oxana Galenko 3, Jeffrey L Anderson 3 4, Joseph B Muhlestein 3 4

This study gave 50,000 IU of vitamin D the night before and the 2 days after the surgery There would probably be more benefit to the body     if the same amount were given several days before the surgery,     as it takes the body a while to utilize the vitamin D         >200.000 IU total in the week before a surgery would be good* Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021* Improve your health BEFORE surgery (prehabilitation) helps your recovery - 2018* '':In many cases taking Vitamin D years before would have elminated the need for the surgery* Vitamin D is needed before many surgeries – many studies and RCTs 1. Trauma and surgery category starts with the following{include}---Personal note: 200,000 IU vitamin D helped my 100 year old in ICUMy 100 year-old father-in-law had sepsis while in the ICUI gave him 200,000 IU of vitamin D - without the doctor's knowledgeHe was kicked out of the ICU and hospital 3 days later - sepsis gone and he was all recovered

📄 Download the PDF from Vitamin D Life

image

150,000 IU given late showed minimal benefit

image

Low vitamin D (serum or plasma 25-hydroxyvitamin D (25( OH)D )) is a global pandemic and associates with a greater prevalence in all-cause and cardiovascular mortality and morbidity. Open-heart surgery is a form of acute stress that decreases circulating 25(OH)D concentrations and exacerbates the preponderance of low vitamin D in a patient population already characterized by low levels. Although supplemental vitamin D increases 25(OH)D, it is unknown if supplemental vitamin D can overcome the decreases in circulating 25(OH)D induced by open-heart surgery. We sought to identify if supplemental vitamin D protects against the acute decrease in plasma 25(OH)D propagated by open-heart surgery during perioperative care.

Participants undergoing open-heart surgery were randomly assigned (double-blind) to one of two groups: (a) vitamin D (n = 75; cholecalciferol, 50,000 IU/dose ) or (b) placebo (n = 75). Participants received supplements on three separate occasions: orally the evening before surgery and either orally or per nasogastric tube on postoperative days 1 and 2 . Plasma 25(OH)D concentrations were measured at baseline (the day before surgery and before the first supplement bolus), after surgery on postoperative days 1, 2, 3, and 4, at hospital discharge (5-8 days after surgery), and at an elective outpatient follow-up visit at 6 months.

Supplemental vitamin D abolished the acute decrease in 25(OH)D induced by open-heart surgery during postoperative care. Moreover, plasma 25(OH)D gradually increased from baseline to day 3 and remained significantly increased thereafter but plateaued to discharge with supplemental vitamin D. We conclude that perioperative vitamin D supplementation protects against the immediate decrease in plasma 25(OH)D induced by open-heart surgery. ClinicalTrials.gov Identifier: NCT02460211.

Tags: Loading dose Trauma and surgery