Supplements that improve Vitamin D genes

Vitamin D Life - Genetics chart, ✻ are not seen by Vitamin D test

Perplexity AI June 2025

Glutathione details

1. Multi-enzyme regulation : Upregulates CYP2R1 (25-hydroxylase) 4, CYP27A1 (mitochondrial hydroxylase) 1, and CYP27B1 (1α-hydroxylase) 1 3 while suppressing CYP24A1 (catabolic enzyme) 1 3.

2. VDBP enhancement : Increases both mRNA and protein expression of vitamin D binding protein in hepatocytes 1 4, extending 25(OH)D half-life.

3. VDR synergy : Restores VDR expression in glutathione-deficient renal cells 3 and amplifies VDR-mediated transcriptional responses through AP-1 signaling 5.

4. Oxidative stress link : Glutathione deficiency causes reciprocal dysregulation - ↓ CYP27B1/VDR and ↑ CYP24A1 1 3, creating vitamin D resistance.

   Citations

5. https://pmc.ncbi.nlm.nih.gov/articles/PMC6208166/

6. https://www.grassrootshealth.net/blog/vitamin-d-glutathione-nac-important-relationships-pay-attention/

7. https://pubmed.ncbi.nlm.nih.gov/30578920/

8. https://mdanderson.elsevierpure.com/en/publications/l-cysteine-supplementation-upregulates-glutathione-gsh-and-vitami

9. https://www.mdpi.com/1422-0067/25/4/2284

10. https://www.nature.com/articles/s41420-024-01912-9

11. https://www.mdpi.com/2073-4409/12/2/335

12. https://pubmed.ncbi.nlm.nih.gov/31616013/

13. https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202201400R

14. https://www.ncbi.nlm.nih.gov/gene/1591

Earlier Perplexity detailed report

📄 Perplexity PDF

See also Vitamin D Life

• Note: poor response to Vitamin D test, not poor response of vitamin D getting to cells _

  • Response to Vitamin D – 25% high, 24% low (ignores other than genes) – July 2024

  • Response to Vitamin D - many studies

• Many genes can restrict Vitamin D from getting to the cells – Aug 2023

• Review of 11 Vitamin D genes – Nov 2017

• Glutathione master antioxidant, improves many vitamin D genes, about 20 cents per day

• Resveratrol

  • Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023

  • COVID-19 Cytokine storms attenuated by Vitamin D, Omega-3, Mg, Resveratrol, etc – April 2021

  • Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018

  • Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020

  • Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies

  • Resveratrol Efficacy improvements – special issue 2017

• Vitamin D Receptor

  • Vitamin D Receptor deactivated by some health problems - many studies

  • VDR category is associated with these 49 other Vitamin D Life categories as of 2024

    • Genetics 74, Binding Protein 46, Virus 33, CYP27B1 32, Pregnancy 24, Breathing 24, Diabetes 23, Cancer 22, Infant-Child 21, Cancer - Breast 19, Autoimmune 18, Resveratrol 18, Cognitive 16, Obesity 16, Osteoporosis 13, Cancer - Colon 13, Gut 13, Immunity 12, Parkinson 11, Cancer - Other 11, Seniors 10, Rheumatoid Arthritis 10, Cancer - Skin 10, Multiple Sclerosis 10, Hypertension 9, Vision 8, Tuberculosis 8, Skin 7, Thyroid 7, Skin - Dark 7, Cancer - Prostate 7, Back pain 7, Fertility and sperm 6, Dental 6, Women 6, Cancer - Ovarian 6, Bone - Health 6, Sports 6, Cardiovascular 6, Lupus 6, Cancer - after diagnosis 5, UV 5, Liver 5, Intervention 4, Autism 4, Deficiency 4, Books & videos 4, Mortality 4, Stroke 4, Middle East 4, Kidney 4, Cancer - Lung 4, Cancer - Bladder 4

• Vitamin D Binding Protein

  • No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023

  • Autism has a 2.5 X higher risk of being severe if poor Vitamin D Binding gene – Nov 2024

  • No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022

  • T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022

  • Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022

• CYP27B1

  • COVID maximum downregulation of Vitamin D receptor and CYP27B1 resulted in death - Feb 2024

  • Miscarriage (Recurrent Spontaneous) associated with poor CYP27B1 gene - Jan 2024

  • Every Parkinson’s brain had a gene modification that limited how much vitamin D was available (CYP27B1) – Feb 2022

• CYP24A1 gene and Vitamin D - many studies

  • Suppression of CYP24A1 gene got more Vitamin D to cells to fight Breast Cancer – March 2023

  • No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023

  • Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1) – Oct 2021

  • Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020

• CYP34A4

  • Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022

  • Ivermectin decreases CYP3A4

• CYP2R1 detected by Vitamin D test

  • Autoimmune diseases and poor Vitamin D genes – GC, CYP2R1, CYP27B1, and VDR – April 2024

  • COVID-19 5X worse if poor Vitamin D gene (CYP2R1) – June 2021

  • Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013