Sudden cardiac arrest 6X worse outcome if low vitamin D

Created December 2014

Vitamin D Deficiency Is Associated with Poor Neurological Outcome After Sudden Cardiac Arrest: Abstract 302:

Resuscitation Science Symposium Nov 2014

Jin Wi1; JaeSun Uhm2; Boyoung Joung2; Hui-Nam Pak2; Moon-Hyoung Lee2

1 Cardiology, Severance Cardiovascular Hosp, Yonsei Univ Health System, Seoul, Korea, Republic of

2 Severance Cardiovascular Hosp, Yonsei Univ Health System, Seoul, Korea, Republic of

| | | | || --- | --- | --- | --- || Vitamin D Level | neurologic outcome | % of SCA | Mortality || 8 ng | poor | 59 % | 28 % || 12 ng | good | 18% | 0 % |Note: NONE of the SCA with higher vitamin D diedNote: <10 ng vitamin D = deficient in Korea Perhaps the lowest in the world 1. See also Vitamin D Life* CPR with low vitamin D – 10X more likely to have poor outcome within 3 months – Jan 2022* Overview Cardiovascular and vitamin D* Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019* 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013* Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012* Far better to take Vitamin D than a baby aspirin to avoid heart problems* * *baby aspirin reduction < 6% best, Vitamin D decreased death by aobut 100X more* *

Background: Vitamin D deficiency has been reported to be related to various cardiovascular diseases, including sudden cardiac arrest (SCA). This study investigated the association of vitamin D deficiency with neurologic outcome after SCA.

Methods: We prospectively analyzed clinical data from all unconscious patients resuscitated from a SCA of presumed cardiac cause. Neurologic outcome was assessed by Cerebral Performance Category (CPC) score at 6 months after discharge. Good neurologic outcome was defined as CPC score of 1 or 2, whereas poor one as CPC scores of 3 through 5. Vitamin D deficiency was defined as 25(OH)D <10 ng/mL.

Results: A total of 65 patients [51 men (79%), mean age 59 ± 14 years] were included from May 2012 to October 2013 in this study. First monitored rhythm was shockable rhythm, including ventricular fibrillation or tachycardia, in 44 (68%) and non-shockable rhythm, including pulseless electrical activity or asystole, in 21 (32%). Bystander cardiopulmonary resuscitation (CPR) was performed in 51 (79%) and mean arrest time and CPR time were 26 ± 20 min and 22 ± 18 min, respectively. The mean vitamin D level was 10.5 ± 5.3 ng/mL and vitamin D deficiency was observed in 39 (60%) patients.

Vitamin D level was significantly lower among patients with poor neurologic outcome than in those with good outcome (8.0 ± 3.8 vs. 12.1 ± 5.6 ng/mL, p=0.001).

Patients with vitamin D deficiency were likely to have more poor neurologic outcome (59 vs. 18%, p=0.001) and mortality (28 vs. 0%, p=0.002).

In multivariate logistic analysis, vitamin D deficiency ( OR 6.72 , 95% CI 2.03-22.26, p=0.002) was the significant independent predictor of poor neurologic outcome after SCA with absence of bystander CPR, first monitored non-shockable rhythm, and baseline renal dysfunction.

Conclusion: Vitamin D deficiency is the important independent predictor of poor neurologic outcome following SCA.

Tags: Cardiovascular