Stroke

Stroke Category highlights - includes post-stroke

items in stroke category  - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D   Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

• Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017

• Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015

• Ischemic stroke 17 X more likely if low vitamin D – April 2017

• Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018

• Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014

  Post-Stroke worse if low Vitamin D

• Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023

• Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019

• Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020

• Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019

• Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015

• Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018

• Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019

  Post-Stroke better if add Vitamin D

• Post-stroke Vitamin D supplementation helped in 11 ways – May 2023

• Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018

• Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017

• Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016

• Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019

  Post-Stroke better if Vitamin D actually gets to cells

• Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018

• Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020

  studies in both categories of Depression and Stroke

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Post-Stroke depression is 3.5X more-likely if vitamin D deficient - meta-analysis - Aug 2024

Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis

Journal of Geriatric Psychiatry and Neurology https://doi.org/10.1177/08919887241275044

  It says PDF is behind a paywall, but also says that it is available via creative common liscnse

Yongjun Tan, PhD, Xiaojun Jing, MD, […], and Qin Yang, PhD https://orcid.org/0000-0003-4040-1661 [email protected]+4

To conduct the association between vitamin D levels in the acute phase of stroke and post-stroke depression (PSD) in stroke patients.

Methods

Five international databases (PubMed, Web of Science, Embase, Ovid MEDLINE(R), Cochrane Library) and one Chinese database (Wanfang Data) were searched for observational studies in any language reporting on PSD and vitamin D levels tested in the acute phase of stroke in stroke patients from inception to May 2024. Data extraction and study quality assessment were conducted by two authors independently. Qualitative and quantitative analyses of data were performed. The meta-analysis was registered in the PROSPERO database (CRD42023398581).

Results

We included 7 studies containing 3537 participants in the systematic review and meta-analysis. All studies that met the inclusion and exclusion criteria were conducted in China. Vitamin D levels in the acute phase of stroke were lower in PSD patients compared with non-PSD patients (weighted mean difference = −14.97 nmol/L; 95% confidence interval = −19.54, −10.40).

Stroke patients with vitamin D deficiency (<50 nmol/L) had an increased risk of PSD compared with stroke patients with vitamin D sufficiency (≥75 nmol/L) ( odds ratio = 3.59 ; 95% confidence interval = 2.05, 6.27). However, the association between vitamin D insufficiency (50-75 nmol/L) and PSD were not statistically significant (odds ratio = 4.15; 95% confidence interval = 0.87, 19.78).

Conclusion

Vitamin D deficiency in the acute phase of stroke may be a risk factor for PSD.

20 Most-visited pages in the Stroke category in Vitamin D Life

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All Stroke items

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Vitamin D Life - studies in both categories Depression and Stroke

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Stroke is associated with categories: Cardiovascular 14, Cognitive 13, Hypertension 10, Depression 9, Intervention 7, Mortality 6, Diabetes 5, Skin - Dark 5, Virus 5, Injection 4, Vitamin D Receptor 4,

Detailed Associations with the Stroke Category

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