Staph infections with eczema reduced with 2,000 IU of vitamin D – RCT

Created February 2016

The Effects of Oral Vitamin D Supplement on Atopic Dermatitis: A Clinical Trial with Staphylococcus aureus Colonization Determination.

J Med Assoc Thai. 2015 Oct;98 Suppl 9:S23-30.

Udompataikul M, Huajai S, Chalermchai T, Taweechotipatr M, Kamanamool N.

Used 2,000 IU daily for 4 weeksEven far better benefits expected if had used any/all of the following1. Loading dose – Consume 350,000 IU of vitamin D in a week1. Higher daily dose – say 4,000 IU1. Longer dosing period – say 8 or 12 weeksSee also Vitamin D Life* Evidence indicating that vitamin D deals with microorganisms in atopic dermatitis – Jan 2015* Atopic Dermatitis risk is 55 percent higher if low vitamin D – Meta-analysis Oct 2015* Skin physiology, pathology and vitamin D - review Jan 2016 90% of Atopic Dermatitis have staph infection* Staph infection reduced 50 percent when have more than 30 ng of vitamin D – Aug 2011* MRSA inpatient cost 2X higher if less than 20 ng vitamin D – June 2011* MRSA = Methicillin Resistant Staphylococcus Aureus* Sepsis is both prevented and treated by Vitamin D - many studies

BACKGROUND:

An increase in Staphylococcus aureus skin colonization in atopic dermatitis patients resulted from the reduction of cathelicidin production in these patients. Recently, an in vivo study demonstrated that vitamin D could stimulate cathelicidin production. Oral supplements of vitamin D might be beneficial in atopic dermatitis.

OBJECTIVE:

To determine the effects of oral vitamin D supplements on clinical impact including Staphylococcus aureus skin colonization evaluation in atopic dermatitis patients.

MATERIAL AND METHOD:

Twenty-four atopic dermatitis patients were included in this double-blind, placebo-controlled study. They were randomly assigned into 2 groups for oral 2,000 IUs/day of vitamin D, supplement and placebo. The lesional swab culture for S. aureus was done at week 0, 2 and 4. Clinical outcomes were assessed by SCORAD score, mexameter for erythema index and konometer for conductance were done at week 0, 2 and 4. Serum vitamin D levels were also determined at week 0 and 4.

RESULTS:

Twenty patients completed the protocol. S. aureus skin colonization, SCORAD score and erythema index were significantly reduced from baseline to week 4 for vitamin D treated group comparing with placebo (p = 0.022, 0.028 and 0.014, respectively). There was an inverse correlation between serum vitamin D levels with S. aureus skin colonization and SCORAD score (r = -1.0, p < 0.001).

CONCLUSION:

Oral vitamin D supplement could reduce skin colonization of S. aureus and demonstrated the clinical improvement of patients with atopic dermatitis.

PMID: 26817206