Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease

Created March 2017

Vitamin D Status in Chronic Kidney Disease - UVB Irradiation Is Superior to Oral Supplementation.

Anticancer Res. 2016 Mar;36(3):1397-401.

Krause R1, Roth HJ2, Kaase H3, Stange R4, Holick MF5.

People with poor digestion (CKD, Diabetes, MS, etc) are not able to get much benefit from standard oral Vitamin D. The study on this page shows if UV is given to those with CKDStudy on this page found with UV that:* More vitamin D gets into the bloodstream than with oral* Vitamin D receptor improved by 65% * (which increases the active vitamin D actually getting into the cells)* CYP27B1 gene improved by 100% * (which increases activation of Vitamin D in the Kidney )* CYP2R gene improved by 120% 1. See also Vitamin D Life* * * articles in Genetics category* All items in sub category Vitamin D Receptor items* Search Vitamin D Life for Cyp2R1 412 hits Dec 2016** 1. Poor guts need different forms of vitamin D{include} 1. See also webSearch Google for "Chronic Kidney Disease" and Digestion: 473,000 hits as of March 2017

BACKGROUND:

In chronic kidney disease (CKD) a deficiency of 1,25-dihydroxyvitamin D is common. The aim of this review was to compare vitamin D status after oral supplementation of vitamin D3 to that of serial suberythemal irradiation in end-stage kidney disease (ESKD) patients.

PATIENTS AND METHODS:

Ninety-five patients, with a mean age of 62 (range=35-82) years, were treated with a mean dose of 35,000 (20,000-60,000) IU vitamin D3 per week for a period of 18 months. Fourteen patients, with a mean age of 51 (range=41-57) years, were whole-body UVB irradiated for over 6 months. From 3 hemodialysis patients skin biopsies were performed.

RESULTS:

With oral supplementation 25(OH)D3 increased by 60%. With UV irradiation 25(OH)D3 increased by 400%. Gene expression analysis demonstrated an improvement in the vitamin D receptor (VDR) by 0.65 fold, in 1-alpha-hydroxylase (CYP27B1) by 1.0 fold, and in 25-hydroxylase (CYP2R) by 1.2 fold.

CONCLUSION:

Serial suberythemal UVB irradiation of patients with CKD on dialysis is capable to improve serum 25(OH)D3 and 1,25(OH)2D3 by enhancing the skin's ability to activate vitamin D.

PMID: 26977042

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Tags: Forms Kidney