Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D
Vitamin D Deficiency and Comorbidities in Children with Sickle Cell Anemia
Pediatr Hematol Oncol. 2012 Apr;29(3):261-6. (doi:10.3109/08880018.2012.661034)
Tara Christine Jackson,1 Melissa Jo Krauss, MPH,2 Michael Rutledge DeBaun, MD, MPH,3 Robert Charles Strunk, MD,4 and Ana Maria Arbeláez, MD, MSCI4
1 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
2 Division of Biostatistics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
3 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA; and Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
4 Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA
Address correspondence to Ana Maria Arbeláez, MD, MSCI, Division of Pediatric Endocrinology, Washington University in St. Louis,
School of Medicine, 660 South Euclid, Campus Box 8116-NWT, St. Louis, MO 63110–1077, USA. E-mail: [email protected]
Vitamin D deficiency is known to be common among patients with sickle cell anemia (SCA).
Vitamin D levels were measured in 139 children (aged 7.9 to 15.1 years) to study its association with SCA morbidities;
severe deficiency <10 ng/mL was present in 64.0% and only 2.2% were sufficient (>30 ng/mL).
Vitamin D levels
were associated with pulmonary function (forced expiratory volume in 1 second [FEV1]), but
not associated with either rates of acute pain or acute chest syndrome episodes.
Further studies are needed to be able to compare outcomes in those with deficiency to those with sufficiency, as well as to treating patients with SCA with vitamin D to better establish a possible link, if any, between vitamin D and SCA morbidity.
See also Vitamin D Life
Overview Dark Skin and Vitamin D - typically very low on vitamin D if not supplemented
Overview Dark Skin Births and Vitamin D
Items in both categories of Bone Health and Dark Skin are listed below
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See also web
- Relationship between vitamin D deficiency and bone fragility in sickle cell disease: A cohort study of 56 adults Oct 2012
- Median 25(OH)D concentration was 6ng/mL.
- Those with < 6ng had 43% probability of having a bone fracture
- The other half with > 6ng had only 18% probability of having a bone fracture
The Role of Nutrition in Sickle Cell Disease Jan 2010 full text on-line
Clinical Trials for Sickle Cell and vitamin D INTERVENTION 3 as of Oct 2012