Sepsis in first year of life is much more likely if preterm (low Vitamin D)
Neonatal and Maternal 25-OH Vitamin D Serum Levels in Neonates with Early-Onset Sepsis
Children 2017, 4(5), 37; doi:10.3390/children4050037
(34 weeks) | Full term
(37.5 weeks) | Ratio || Infants | 2.6 | 17 | 6.5 X || Mothers | 10 | 20 | 2 X | 1. See also Vitamin D Life* Sepsis is both prevented and treated by Vitamin D - many studies* Sepsis accounts for more than 25% of neonatal deaths worldwide.* Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017Healthy pregnancies need lots of vitamin D has the following summary{include}
^ It appears that low premie vitamin D predicted with 95% accuracy that the infant would have sepsis in the first year
"In our study, both of neonatal and maternal 25-OH vitamin D serum levels were good sensitive markers (84% and 82%, respectively) and good specific tests (79% and 77%, respectively) with positive predictive values ( 94.7% and 91.4%, respectively) and negative predictive values (82.3% and 80.6%, respectively) for early detection of neonatal sepsis, and these are in agreement with many previous studies"^
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Taha Soliman Gamal 1, Abd-Allah Sayed Madiha 1, Mostafa Kamel Hanan 2, Mohamed El-Mazary Abdel-Azeem 1,* and Gamil S. Marian 1
1 Pediatric Department, El-Minya University, Minya, 11432, Egypt
2 Clinical-Pathology Department; El-Minya University, Minya 11432, Egypt
Vitamin D is a fat-soluble vitamin that is important for calcium metabolism and plays an important role in the immune functions. The aim of this study was to measure neonatal and maternal 25-OH vitamin D serum levels in neonates with early onset sepsis. The study included fifty neonates with early onset sepsis (25 full-term and 25 preterm infants) and thirty age and sex matched healthy neonates as controls. After history taking and clinical examination, complete blood count, C-reactive protein and 25-OH vitamin D serum levels (neonatal and maternal) were measured for all neonates.
The mean gestational age for neonates with sepsis was (37.5 ± 0.98 for full term and 34.1 ± 1.26 for preterm neonates).
Neonatal and maternal 25-OH vitamin D serum levels were significantly lower in patients (6.4 ± 1.8 and 24.6 ± 2.2 nmol/L) than controls (42.5 ± 20.7 and 50.4 ± 21.4 nmol/L).
Significant negative correlations between neonatal and maternal 25-OH vitamin D serum levels and all sepsis markers and significant positive correlations between neonatal and maternal 25-OH vitamin D levels were present. At cut-off values <20 nmol/L for neonatal and <42 nmol/L for maternal 25-OH vitamin D for detection of neonatal sepsis, the sensitivity, specificity, positive predicted value (PPV) and negative predicted value (NPV) were 84%, 79%, 94.7% and 82.3% for neonatal and 82%, 77%, 91.4% and 80.6% for maternal 25-OH vitamin D, respectively.
Positive correlations between neonatal and maternal 25-OH Vitamin D serum levels are present and they are negatively correlated with all sepsis markers. They can be sensitive early predictors for early onset sepsis in neonates.