Schizophrenia 44 percent more likely if low vitamin D at birth (8 ng)

The association between neonatal vitamin D status and risk of schizophrenia

Scientific Reports volume 8, Article number: 17692 (2018)

Link Between Newborns With Vitamin D Deficiency And Schizophrenia Confirmed Science Blog* "According to John McGrath, schizophrenia is associated with many different risk factors, both genetic and environmental, but the new research suggests that neonatal vitamin D deficiency could possibly account for about 8 per cent of schizophrenia cases in Denmark."---* 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004* Taking Vitamin D after birth reduced chance of schizophrenia 14 years before study on this page* Suspect >77% reduction in those infants who had < 8 ng initially* Schizophrenia associated with low vitamin D – review Dec 2014* Schizophrenia has many associations with low vitamin D – review 2016* Schizophrenia Prevention – Vitamin D is one possibility – Jan 2014 1. Overview Schizophrenia and Vitamin D contains the following summary{include}Note #11:Increase in Dane Schizophrenia after Vitamin D was stopped 1. Types of evidence that Vitamin D helps brain problems - 2014---Healthy pregnancies need lots of vitamin D has the following summary{include}

📄 Download the PDF from Vitamin D Life

Vitamin D levels below 20.4 nmol = 8 ng

Darryl W. Eyles, Maciej Trzaskowski, Anna A. E. Vinkhuyzen, Manuel Mattheisen, Sandra Meier, Helen Gooch, Victor Anggono, Xiaoying Cui, Men Chee Tan, Thomas H. J. Burne, Se Eun Jang, David Kvaskoff, David M. Hougaard, Bent Nørgaard-Pedersen, Arieh Cohen, Esben Agerbo, Carsten B. Pedersen, Anders D. Børglum, Ole Mors, Pankaj Sah, Naomi R. Wray, Preben B. Mortensen & John J. McGrath

Clues from the epidemiology of schizophrenia, such as the increased risk in those born in winter/spring, have led to the hypothesis that prenatal vitamin D deficiency may increase the risk of later schizophrenia. We wish to explore this hypothesis in a large Danish case-control study (n = 2602). The concentration of 25 hydroxyvitamin D (25OHD) was assessed from neonatal dried blood samples. Incidence rate ratios (IRR) were calculated when examined for quintiles of 25OHD concentration. In addition, we examined statistical models that combined 25OHD concentration and the schizophrenia polygenic risk score (PRS) in a sample that combined the new sample with a previous study (total n = 3464; samples assayed and genotyped between 2008-2013).

Compared to the reference (fourth) quintile, those in the lowest quintile (<20.4 nmol/L) had a significantly increased risk of schizophrenia ( IRR = 1.44 , 95%CI: 1.12–1.85). None of the other quintile comparisons were significantly different. There was no significant interaction between 25OHD and the PRS.

Neonatal vitamin D deficiency was associated with an increased risk for schizophrenia in later life.

These findings could have important public health implications related to the primary prevention of schizophrenia.