Review of autoimmune skin diseases and Vitamin D ignores topical form
The role of VD/VDR signaling pathway in autoimmune skin diseases
Mini Rev Med Chem . 2022 Nov 24. doi: 10.2174/1389557523666221124123206 PDF is behind a $95 paywall
Yilan Zeng 1 , Shengbo Yang 1 , Dan Wang 1 , Yuanhong Liu 1 , Ziting Tang 1 , Xuemei Li 1 , Xiule Zong 1
Background: Immune-related cutaneous diseases are a series of disorders, such as
alopecia areata,
psoriasis,
atopic dermatitis,
systemic lupus erythematosus and
autoimmune bullous dermatoses.
Vitamin D is a fat-soluble vitamin, which is known for its classical pleiotropic effect. Recent studies have found that vitamin D, after catalyzed into its biologically active form [1,25[OH] 2D], correlated with its receptor, vitamin D receptor, plays a vital role in multiple pathophysiological processes, including immune-related dermatoses. This review mainly summarizes evidence on the role of vitamin D/vitamin D receptor in immune-related cutaneous diseases and the potential therapeutic targets for skin disorders.
Methods: We have carried out a comprehensive literature search in PubMed and Google Scholar databases using keywords like "vitamin D", "vitamin D receptor", "immune", "psoriasis", "atopic dermatitis", "skin", "systemic lupus erythematosus", "alopecia areata" and "autoimmune bullous dermatoses". Only articles related to the topic were included in this review. Conference, patent, graduation thesis and articles without available full text were excluded.
Results: Vitamin D/vitamin D receptor is critical for skin in regulating the proliferation and differentiation of keratinocytes, keeping the integrity of the skin barrier as well as maintaining the homeostasis of the skin's immune system. Vitamin D deficiency/vitamin D receptor mutations are potential risk factors for some immune-related cutaneous diseases.
Conclusion: Vitamin D is a pleiotropic hormone, which is important in the homeostasis of human body. Many studies have revealed vitamin D deficiency in several skin diseases. Thus, vitamin D supplementation may be a useful therapeutic option for immune-related skin diseases.
Vitamin D Life - Topical Vitamin D contains
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Topical Vitamin D provides more benefits than oral sometimes - many studies
Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
Topical Vitamin D provides more benefits than oral for some people
Skin category listing has items along with related searches
Topical vitamin D raised blood level to 38 ng (used Aloe Vera gel) – RCT March 2014
Topical vitamin D might be more bio-available than oral – Oct 2015
Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
Getting Vitamin D into your blood and cells topical is one of many ways
Vitamin D Life – Psoriasis category contains
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Vitamin D Life – Lupus category contains
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