Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.

Created March 2020

Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

Biomedicine & Pharmacotherapy 109 (2019) 2237–2251

Naveet Pannu, Archana Bhatnagar

Department of Biochemistry, BMS block-II, Sector 25, Panjab University, Chandigarh, India

* Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc** Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activatorsResveratrol improves health (Vitamin D receptor, etc.) - many studies has the following{include}---Items in both categories Resveratrol and Cognitive are listed here: {category}Items in both categories Resveratrol and Diabetes are listed here: {category}Items in13oth categories Resveratrol and Cardiovascular are listed here: {category}Items in both categories Resveratrol and Stroke are listed here: {category}

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Resveratrol, a phytoalexin with a wide range of pharmacological properties is synthesised by plants in response to stress, injury, infection or UV radiations. As it is a secondary metabolite with many health promoting properties, various methods employing microorganisms and genetic manipulation of different synthetic enzymes, have been comprehensively studied to increase its production. Its rapid metabolism and low bioavailability have been addressed by the use of bio enhancers and nano-formulations. This flavonoid is extensively researched due to its pharmacological properties such as anti-oxidative, anti-inflammatory and immuno-mod- ulating effects. Knowledge of these properties of resveratrol has led to elaborate studies on its effect on diabetes, neurodegenerative diseases, cancer, ageing, obesity and cardiovascular diseases. At molecular level it targets sirtuin, adenosine monophosphate kinase, nuclear Factor-KB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as angiogenesis, apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism. This review discusses the properties of resveratrol and the different approaches of addressing the unfavourable synthesis and pharmacokinetics of this stilbene. Pre-clinical evaluations of resveratrol on diabetes mellitus, cardiovascular and neurological diseases are elaborately discussed and the underlying pathways involved in its therapeutic activity have been given paramount importance. Following the pre-clinical studies, clinical trials on the same reveal the efficacy of resveratrol in the effective management of these diseases. This review provides an intricate insight on resveratrol’s significance from a dietary

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Tags: Cardiovascular Cognitive Diabetes Parkinson's Resveratrol Stroke