Response to 1,000 IU of vitamin D daily for 6 months – 40 percent above 30 ng (small study)

Necessity of daily 1000-IU vitamin D supplementation for maintaining a sufficient vitamin D status

J Med Invest. 2022;69(1.2):135-140. doi: 10.2152/jmi.69.135.

Yuya Ikezumi 1, Yasushi Matsuura 1, Teruhiro Morishita 1, Noriko Ide 1, Isao Kitada 1, Takafumi Katayama 2, Rie Tsutsumi 3, Hiroshi Sakaue 3, Yutaka Taketani 4, Koichi Sairyo 5, Eiji Takeda 1

The changes in the serum 25-hydroxyvitamin D (25(OH)D) concentrations after daily 1000-IU vitamin D intake for 3 months (3-month-VD), 6 months (6-month-VD) and then 6-month cessation of vitamin D in-take (6-month-VD cessation) were examined. The serum 25(OH)D levels in 11 male and 16 female subjects were 12.1±3.5 ng/mL at baseline, increased to 27.1±4.7 ng/mL at 3-month-VD, 28.5±5.1 ng/mL at 6-month-VD and decreased to 16.4±4.0 ng/mL at 6-month-VD cessation. The present study suggested that a vitamin D intake of 1000 IU/day is required to maintain the 25(OH) D concentration at 30 ng/mL or higher without vitamin D intoxication

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