Respond to daily Vitamin D in 2-12 months

Most responses to daily oral Vitamin D plateau in 2 or 3 months

Grassroots Health

Perhaps much slower response time if person is not healthy/ is needing lots of vitamin D

• Response to Vitamin D sometimes takes a year

• Ensure a healthy pregnancy and baby - take Vitamin D before conception has the following

Vitamin D Levels Plateau typically in 11 weeks (Vitamin D starts to help in about half that time)

• Defining normal level of vitamin D (need 4000-5000 IU) - Heaney Spring 2013 11 weeks
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• Vitamin D every 25 days may be BETTER than daily – RCT May 2018 > 11 weeks
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• 3 to 6 months to plateau with 4,000 IU vitamin D daily (Cardiac Patients) – June 2017 14? weeks
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• Pregnancy #00F:20 weeks
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• 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT March 2013 4 weeks if pre-load
  •     70,000 IU pre-load +35,000 IU weekly dose
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Many Vitamin D trials last 3 months or less

However, sometimes responses do not plateau for 4-12 months

No one seems to know why some people respond slowly

Slow responses might be due to differences in

• Genetics – activation of genes can change over months

  • Note: Activation/deactivation of 6 genes is not noticed by a vitamin D blood test

• Age

  • Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016

• Approximately 10% of people are NON-RESPONDERS

  • Wonder how many non-responders are actually just slow responders

• Pre-existing conditions – such as removed gallbladder, poor liver or kidney

  • 3 to 6 months to plateau with 4,000 IU vitamin D daily (Cardiac Patients) – June 2017

• Gut adjustment – may take many months for gut bacteria to become efficient at absorbing Vitamin D

• Initial Vitamin D level

  • Suspect a different response time if start at low vs high level of vitamin D

• Compliance increased AFTER person notices benefit

  • 4,000 IU of Vitamin D daily is safe, but takes a year to plateau (Best-D) – RCT Dec 2016
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• Reduced some drugs, smoking, stress, etc after getting benefit from vitamin D ==> which increased Vitamin D levels in body

• Obesity

Example Heaney 2003: 38 years old, healthy, men

Doubt that the response is the same for:

    very young, very old, unhealthy, females, starting with >50 ng or < 10 ng, etc.

A loading dose increases Vitamin D levels 30X faster

Loading Dose of Vitamin D category has the following

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10,000 IU of Vitamin D for 7 years with no excessive Calcium in 4,800 patients – Dec 2018

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