Reduce 4 health problems by a quarter if increase Vitamin D to 30 ng – Saudi Arabia, Grant
Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
Biomedicines 2023, 11(4), 994; https://doi.org/10.3390/biomedicines11040994
by William B. Grant 1ORCID,Fatme Al Anouti 2,ORCID,Barbara J. Boucher 3ORCID,Hana M. A. Fakhoury 4ORCID,Meis Moukayed 5ORCID,Stefan Pilz 6 and Nasser M. Al-Daghri 7,ORCID
1 Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USA
2 Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi P.O. Box 144534, United Arab Emirates
3 The Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London E12AT, UK
4 Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia
5 School of Arts and Sciences, American University in Dubai, Dubai P.O. Box 28282, United Arab Emirates
6 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
7 Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Authors to whom correspondence should be addressed
PDF Table of Contents
Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as
Alzheimer’s disease,
autoimmune diseases,
cancers,
cardiovascular disease (ischaemic heart disease and stroke),
type 2 diabetes,
hypertension,
chronic kidney disease,
stroke, and infectious diseases such as acute respiratory tract diseases,
COVID-19,
influenza, and pneumonia, as well as
adverse pregnancy outcomes.
The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to use the best available evidence on the potential beneficial effects of vitamin D to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in the Kingdom of Saudi Arabia and the United Arab Emirates if minimum serum 25(OH)D concentrations were to be raised to 30 ng/mL.
Estimated reductions by
25% for myocardial infarction incidence,
35% for stroke incidence,
20 to 35% for cardiovascular disease mortality, and
35% for cancer mortality rates
depicted a promising potential for raising serum 25(OH)D.
Methods to increase serum 25(OH)D concentrations at the population level could include
food fortification with vitamin D3,
vitamin D supplementation,
improved dietary vitamin D intake, and
sensible sun exposure.
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Getting most of the population >50 ng would provide far more benefits
Health can be greatly improved by weekly 50,000 IU of Vitamin D - video Lahore - March 2023