Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies

Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin - March 2016

Biomol Ther (Seoul). 2016 Mar 1;24(2):191-8. doi: 10.4062/biomolther.2015.122.

Lee KY1, Choi HS2,3, Choi HS3, Chung KY4, Lee BJ1, Maeng HJ5, Seo MD2,3.

The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calcium homeostasis, bone mineralization, and cell differentiation. Quercetin is a widely distributed flavonoid in nature that is known to enhance transactivation of VDR target genes. However, the detailed molecular mechanism underlying VDR activation by quercetin is not well understood. We first demonstrated the interaction between quercetin and the VDR at the molecular level by using fluorescence quenching and saturation transfer difference (STD) NMR experiments. The dissociation constant (Kd) of quercetin and the VDR was 21.15 ± 4.31 µM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR. The binding mode of quercetin was investigated by a docking study combined with molecular dynamics (MD) simulation. Quercetin might serve as a scaffold for the development of VDR modulators with selective biological activities.

📄 Download the 2016 PDF from Vitamin D Life

Vitamin D Receptor category has the following

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Vitamin D Life pages containing QUERCETIN in the title

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See also web

• Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells
  • Jan 2016, "human intestinal Caco-2 cells"
• Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults. July 2015, free PDF
  • "CONCLUSION: The findings obtained demonstrate that long-term vitamin D and quercetin supplementation, alone or in combination, does not improve physical performance in male adults with adequate vitamin D, testosterone, and antioxidant status."
• Risk of prostate cancer in African-American men: Evidence of mixed effects of dietary quercetin by serum vitamin D status. Sept 2015
  • 9% less likely to have PC if have quercetin in the diet (not supplement) not statistically significant
  • 📄 Download the PDF from Vitamin D Life
  • " In individuals with vitD deficiency, increased dietary quercetin showed a tendency toward lower risk of PCa (OR = 0.91, 95%CI: 0.82-1.00; P = 0.054, age-adjusted) while men with normal vitD were at elevated risk (OR = 1.23, 95%CI:1.04-1.45)."

• Quercetin supplement benefit and side effects, a flavonoid used for prostate, allergy, blood vessel health, athletic performance, Drug interactions, influence on allergy and how to best use this product without adverse reactions Feb 2017

• 22 Scientifically Proven Benefits of Quercetin Selfhacked, excellent overview,

  • Vitamin D is not mentioned, but it appears that all 22 items are also related to Vitamin D
  • 1) Quercetin Protects the Brain, 2) Quercetin Might Heal Leaky Gut, 3) Quercetin is Anti-inflammatory, 4) Quercetin May be Anti-Aging, 5) Quercetin May Prevent Cancer, 6) Quercetin Reduces the Histamine Response, 7) Quercetin is Antibacterial, 8) Quercetin Limits, and Protects Against, Obesity, 9) Quercetin May Prevents and Treat Diabetes, 10) Quercetin Reduces Symptoms of Arthritis, 11) Quercetin is Good For Your Heart. 12) Quercetin May Reduce Allergies, 13) Quercetin Enhances the Immune System, 14) Quercetin is Good for Athletic Endurance, 15) Quercetin Reduces Blood Pressure, 16) Quercetin May Protect the Liver, 17) Quercetin May Protect the Kidneys

• Amazon US had 613 products with quercetin as of May 2017

• Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. Oct 2016, PDF is available at https://www.deepdyve.com

  • "In conclusion, quercetin, 3-hydroxyflavone, galangin, datiscetin, kaempferol, morin, isorhamnetin, tamarixetin, myricetin, and syringetin are not agonists of rVDR, mVDR, or hVDR, as judged by cell-based and in silico evidence."
• Wikipedia
  • "While quercetin supplements have been promoted for prevention and treatment of cancer, "there is no reliable clinical evidence that quercetin can prevent or treat cancer in humans".^[2]"

• quercegen.com| >7,000 studies have been made of quercegen

• https://draxe.com/quercetin/

• Superfioods: red wine, green tea, kale and blueberries all have quercetin (also Broccoli - important for health)

• Quercetin WebMd

  • Quercetin is also in onions, green tea, apples, berries, Ginkgo biloba
  • Known to be safe for 500 mg twice daily for 12 week
  • "Quercetin might decrease how quickly the liver breaks down some medication"

• Quercetin Examine.com

• Quercetin, Vitamin D, Iron, Zinc and Thyroid Function Welness Resources 2017?

• Quercetin extensive review at ConsumerLab Mayl 2022

  • "11 cents to as much as $1.17 to get the same amount of quercetin"

  • You can get a trial membership to see all of their excellent reviews

  • Best was MRM® Quercetin

• Pronunciation: kwer -suh-tin

Web Mercola

• The Wide-Ranging Health Benefits of Quercetin Oct 2023 Mercola

  • 📄 Download the PDF from Vitamin D Life

• Quercetin — A Far Better Flu Remedy Than Tamiflu Mercola Feb 2018

  • RCT: Following exercise stress test:5% viral infection if got Quercetin + Niacin + Vitamin C, 45% if not get it.

• Quercetin and Pterostilbene Mercola April 2019
  • US Military studied Quercetin and developed a supplement for military personnel
  • Mercola form has 20 times the bioavailability, $1/day, money-back guarantee

• Quercetin Boosts Interferon Response to Viruses and COVID-19 Mercola June 1 2020

• More Health Benefits of Quercetin Revealed Mercola Jan 2020 45 references

  • Metabolic Syndrome Improves Diabetes-Induced NAFLD, Helps Modulate Gene Expression (not mention VDR),

  • Powerful Antiviral (Influenza, Herpes, H3N2, H1N1, Dengue (in mice). Combats Inflammation and Boosts Immunity

Found My Fitness Aug 2020 table of contents (the words Receptor and Vitamin do not occur once)

2Quercetin and health

3Quercetin as an antioxidant

4Quercetin and inflammation

5Quercetin and chronic diseases

 5.1Quercetin and cardiovascular disease

 5.2Quercetin and hypertension

 5.3Quercetin and atherosclerosis

 5.4Quercetin and obesity

6Quercetin and wound healing

 6.1Quercetin and viral infections

 6.2Quercetin and rheumatoid arthritis

7Quercetin and exercise

8Quercetin and aging

9Senolytic compounds

10Quercetin as a senolytic compound

 10.1The "hit and run" treatment of senolytics

 10.1Quercetin improves median lifespan in animals

 10.2Quercetin improves age-related vascular conditions

 10.3Quercetin and neurological diseases

 10.4Quercetin and bone loss

 10.5Quercetin and pulmonary fibrosis

 10.6Quercetin and diet-related kidney disease

11Pharmacokinetics

12Quercetin bioavailability and safety profile

23 studies cited this Quercetin - VDR study as of Oct 2023

• Quercetin activates vitamin D receptor and ameliorates breast cancer-induced hepatic inflammation and fibrosis- April 2023 https://doi.org/10.3389/fnut.2023.1158633 FREE PDF

• Role of in vitamin D in irritable bowel syndrome - April 2023 doi: 10.12998/wjcc.v11.i12.2677 FREE PDF

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