Pregnancy complications reduced with 4000 IU of vitamin D - 2RCT
Health Characteristics and Outcomes of Two Randomized Vitamin D Supplementation Trials during Pregnancy: A Combined Analysis.
J Steroid Biochem Mol Biol. 2013 Jan 10. pii: S0960-0760(13)00006-X. doi: 10.1016/j.jsbmb.2013.01.002.
Wagner CL, McNeil RB, Johnson DD, Hulsey TC, Ebeling M, Robinson C, Hamilton SA, Hollis BW.
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC; Eau Claire Cooperative Health Centers, Columbia, SC. Electronic address: [email protected].
OBJECTIVE: To assess the safety and health effects of vitamin D supplementation during pregnancy. Methods and Design: Datasets from two randomized clinical trials were first analyzed separately then combined for this analysis using a common data dictionary. In the NICHD trial, women were randomized to 400, 2000, or 4000 IU vitamin D(3)/day, stratified by race. In the Thrasher Research Fund trial, participants were randomized to 2000 or 4000 IU vitamin D(3)/day. Study drugs were from the same manufacturing lot for both trials. Identical questionnaires were given for comparable sociodemographics & clinical characteristics. Outcome measures were: [1] maternal and neonatal 25(OH)D achieved, and [2] maternal comorbidities of pregnancy (COP). SAS 9.3 was used for all analyses.
RESULTS: In the combined cohort, there were 110 controls, 201 in the 2000 IU group, and 193 in the 4000 IU group. No differences between groups in baseline 25(OH)D were found; however, delivery and cord blood values were greater in the 4000 IU group (p<0.0001), an effect that persisted even after controlling for race and study. A greater percent were vitamin D replete in the 4000 IU group (p<0.0001). There was a trend where the 4000 IU group had decreased rates of comorbidities of pregnancy. There was a strong association between COP and final maternal 25(OH)D ; an effect that persisted even after controlling for race and study (p=0.006).
CONCLUSIONS: Supplementation with 4000 IU/day was associated with lower risk of hypovitaminosis D than Control and 2000 IU groups. While not statistically significant, there was a trend toward lower rates of COP as supplementation dose increased. Maternal delivery 25(OH)D was inversely associated with any comorbidity of pregnancy, with fewer events as 25(OH)D increased. Future studies are needed to confirm these findings and determine the mechanisms of action of such effects.
Copyright © 2013. Published by Elsevier Ltd.
PMID: 23314242
See also Vitamin D Life
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More vitamin D during pregnancy made for higher mental scores at 14 months – Dec 2012
Vitamin D of 32 to 60 ng is needed before, during, and after pregnancy – Dec 2012
Variety of pregnancy problems with low vitamin D – systematic review Sept 2012
Optimal Vitamin D during pregnancy - 4000 IU March 2012 Wagner , Hollis , et al
Hollis shows far healthier pregnancy when take 4,000 IU of vitamin D
No Preeclampsia during pregnancy if more than 60 ng of vitamin D – RCT July 2013 chart made the the RCT on this page
Healthy pregnancies need lots of vitamin D has the following summary
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