Pregnancy complications cut in half by 4,400 IU of Vitamin D
Vitamin D supplementation during pregnancy: Improvements in birth outcomes and complications through direct genomic alteration - Sept 2017
Molecular and Cellular Endocrinology, Volume 453, 15 September 2017, Pages 113-130, https://doi.org/10.1016/j.mce.2017.01.039
Bruce W. Hollis, Carol L. Wagner
with poor VDR | Health Problem || 4 | polycystic ovary syndrome || 3.3 | Pre-term birth || 1.9 | Uterine Fibroids |--- 1. # All articles in both of the categories Pregnancy and Genetics:{category}--- 1. # All articles in both of the categories Pregnancy and Vitamin D Receptor:{category}--- 1. Vitamin D Life pages with HOLLIS or WAGNER in titleThis list is automatically updated{LIST()}
Highlights
• Vitamin D metabolism during pregnancy differs drastically from the nonpregnant state.
• Vitamin D requirements during pregnancy and health effects are reviewed.
• Vitamin D plays a significant role in health outcomes of mother and fetus.
• Direct genomic alterations occur related to maternal vitamin D status.
• Childhood asthma and multiple sclerosis linked with pregnancy vitamin D status.
Pregnancy represents a time of rapid change, including dramatic shifts in vitamin D metabolism. Circulating concentrations of the active form of vitamin D—1,25(OH)2D skyrocket early in pregnancy to levels that would be toxic to a nonpregnant adult, signaling a decoupling of vitamin D from the classic endocrine calcium metabolic pathway, likely serving an immunomodulatory function in the mother and her developing fetus. In this review, we summarize the unique aspects of vitamin D metabolism and the data surrounding vitamin D requirements during this important period. Both observational and clinical trials are reviewed in the context of vitamin D's health effects during pregnancy that include preeclampsia, preterm birth, and later disease states such as asthma and multiple sclerosis. With enhanced knowledge about vitamin D's role as a preprohormone, it is clear that recommendations about supplementation must mirror what is clinically relevant and evidence-based. Future research that focuses on the critical period(s) leading up to conception and during pregnancy to correct deficiency or maintain optimal vitamin D status remains to be studied. In addition, what effects vitamin D has on genetic signatures that minimize the risk to the mother and her developing fetus have not been elucidated. Clearly, while there is much more research that needs to be performed, our understanding of vitamin D requirements during pregnancy has advanced significantly during the last few decades.
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Table of contents
Not a single case of preeclampsia had a Vitamin D level > 70 nanograms/mL
Related in Vitamin D Life
Overview Pregnancy and vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception has the following charts
click on above chart for details
Study started giving vitamin D at 18 weeks, unlikely to see any benefit until 28 weeks
Healthy pregnancies need lots of vitamin D
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks below for details
| ::Problem:: | Vit. D Reduces | Evidence |
| 0. Chance of not conceiving | 3.4 times | Observe |
| 1. Miscarriage | 2.5 times | Observe |
| 2. Pre-eclampsia | 3.6 times | RCT |
| 3. Gestational Diabetes | 3 times | RCT |
| 4. Good 2nd trimester sleep quality | 3.5 times | Observe |
| 5. Premature birth | 2 times | RCT |
| 6. C-section - unplanned | 1.6 times | Observe |
| Stillbirth - OMEGA-3 | 4 times | RCT - Omega-3 |
| 7. Depression AFTER pregnancy | 1.4 times | RCT |
| 8. Small for Gestational Age | 1.6 times | meta-analysis |
| 9. Infant height, weight, head size within normal limits | RCT | |
| 10. Childhood Wheezing | 1.3 times | RCT |
| 11. Additional child is Autistic | 4 times | Intervention |
| 12.Young adult Multiple Sclerosis | 1.9 times | Observe |
| 13. Preeclampsia in young adult | 3.5 times | RCT |
| 14. Good motor skills @ age 3 | 1.4 times | Observe |
| 15. Childhood Mite allergy | 5 times | RCT |
| 16. Childhood Respiratory Tract visits | 2.5 times | RCT |
RCT = Randomized Controlled Trial
Note: There are about 20 other health improvements which are < 1.3 times