Pregnancies starting with high vitamin D often have fewer toxic metals in 3rd trimester

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

Curr Epidemiol Rep (2024). https://doi.org/10.1007/s40471-024-00348-0

Mandy Fisher, Hope A. Weiler, Jordan R. Kuiper, Michael Borghese, Jessie P. Buckley, Robin Shutt, Jillian Ashley-Martin, Anita Subramanian, Tye E. Arbuckle, Beth K. Potter, Julian Little, Anne-Sophie Morisset & Anne Marie Jukic

Purpose of Review

To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.

Recent Findings

We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.

Summary

Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.

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