Patent to include anti-oxident with vitamin D – 2010

(WO2010075537) FORMULATIONS COMPRISING VITAMIN D OR DERIVATIVES THEREOF

Clipped from patent

“However, cholecalciferol is seen to be very unstable and is especially unstable in the presence of oxygen . It has therefore been difficult to provide formulations of cholecalciferol which are stable. This lack of stability may often be detected as a drop in the level of cholecalciferol in a formulation measured using a cholecalciferol assay.”

“The present invention provides a stable pharmaceutical delivery system comprising vitamin D or derivatives thereof, preferably cholecalciferol. In a first aspect, the present invention provides a pharmaceutical delivery system comprising: i) an inert core, ii) an inner layer comprising vitamin D or a derivative thereof, preferably cholecalciferol, an emulsifier and an anti-oxidant, and iii) an outer protective layer.”

Owner of patent = TEVA PHARMACEUTICAL INDUSTRIES, US

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Wonder if oxidation is a portion of the reason that vitamin D does not appear to be very bio-available in a solid multi-vitamin