Omega-3 may treat schizophrenia
Omega-3 reduces many psychiatric disorders – 2 reviews 2016
in Vitamin D Life Omega-3 reduces many psychiatric disorders – 2 reviews 2016
Attached 2016 PDF is from German University - Undergraduate?
Abstract
Ever since the emergence of the hypothesis that linked the aetiology of schizophrenia with abnormal
membrane phospholipids composition, an increasing number of evidences have suggested reduced
membrane polyunsaturated fatty acids in patients with schizophrenia. This has led to a conduct of several
studies to evaluate the efficacy of omega-3 fatty acid supplement in the modification of membrane
phospholipids and treatment of schizophrenia. The two main omega-3 fatty acid classes, EPA and DHA,
play a vital role in membranes. This project work reviews omega-3 fatty acid studies and summarizes their
outcomes. Eight original articles (nine studies) were reviewed. Six out of nine studies measured RBC
membrane fatty acids levels and all six studies reported a significant increase in EPA after EPA
supplement. Two studies reported increased DHA post omega-3 fatty acid and DHA supplement,
respectively. One study observed a dose-dependent increment in DHA after EPA supplement. Improved
symptoms were observed in seven studies, while one study found a worsening of symptoms in patients
with low baseline PUFA. Moreover, out of the six studies that evaluated the correlation between symptom
change and membrane fatty acids change, three studies observed a correlation between increased EPA and
symptom improvement. One study reported an increased AA associated with improved symptoms, in
contrast to another study, which found a correlation between increased AA and worsened symptoms. The
conclusion from this project work is that EPA supplement can increase the EPA levels in membranes;
however, its therapeutic effect in schizophrenia requires further investigation using larger studies.
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Omega 3 Fatty Acids: Novel Neurotherapeutic Targets for Cognitive Dysfunction in Mood Disorders and Schizophrenia?- 2015
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Design of an Omega-3 first-episode schizophrenia trial- May 2015
Omega-3 fatty acids in first-episode schizophrenia - a randomized controlled study of efficacy and relapse prevention (OFFER): rationale, design, and methods.
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Omega-3 helps.d early schizophrenia - meta-analysis - Nov.t 2015
[Publisher wants $12 for PDF]
People with schizophrenia and depression have a low omega-3 index - June 2016
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