Obese women deficient in both Vitamin D and Vitamin B12

Created March 2018

The relationship between the vitamin serum 25(OH)D and the B12 concentrations in obese women.

Minerva Med. 2018 Apr;109(2):79-87. doi: 10.23736/S0026-4806.17.05447-7. Epub 2017 Nov 7.

Curic N1, Ilincic B1, Milic N2, Cabarkapa V1, Nikolic S1, Medic-Stojanoska M3, Pellicano R4, Abenavoli L5,6.

1 Center for Laboratory Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

2 Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

3 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.

4 Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy.

5 Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia - [email protected].

6 Department of Health Sciences, University "Magna Græcia", Catanzaro, Italy.

Obese women| | | || --- | --- | --- || Vitamin D: | 80% | <20 ng/ml || Vitamin B12: | 66% | < 221 pmol/L |This is an association study. Do not know if low Vitamin ==> Obesity or if Obesity ==> low vitamin---* * B12 category listing has items along with related searches** * Hypothesis – Vitamin B-12 deficiency is associated with Vitamin D deficiencyOverview Obesity and Vitamin D contains the following summary{include}{include}Click here for 2014 study

BACKGROUND:

In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12) may be the result of different pathophysiological mechanisms, but the possible association between them has not been defined yet. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 levels in middle aged women.

METHODS:

In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis. Vitamin D and VB12 status was assessed by laboratory measurement [serum 25(OH)D levels by electrochemiluminescent immunoassay; VB12 by chemiluminescent microparticle immunoassay].

RESULTS:

Obese women were mostly VD deficient [25(OH)D below 50 nmol/L; 40/50, 80%]. Also, among obese we observed presence of VB12 deficiency [VB12 below 148 pmol/L; 13/50, 26%) and marginal depletion of VB12 level (marginal VB12 status 148-221 pmol/L; 20/50, 40%). All anthropometric indicators of obesity, ECV and TBW were significantly associated with both, 25(OH)D and VB12 (P<0.001) levels. In univariate regression analysis serum level of 25(OH)D was significantly associated with VB12 levels (R2=0.170, P<0.001). In regression models, 25(OH)D was significantly associated with VB12 level, independently of fat mass and extracellular fluid volume.

CONCLUSIONS:

Obesity may negatively affect VB12 level, indirectly, by reducing 25(OH)D level in middle aged women.

PMID: 29115801 DOI: 10.23736/S0026-4806.17.05447-7

Tags: B12 Obesity