Nanoemulsion Vitamin D is faster and better - many studies
Bought and tested several nanoemulsions
Note: The following studies compare ORAL nano vs oil-based vitamin D
TOPICAL nanoemulsion (on skin, inside cheeks, under tongue, inhaled, appear to be even better
non-oral skips the stomach, intestine, liver, and kidneys
and appears to have faster and bigger response
Search for: nanoemulsion response "vitamin d": 6 of 4,990+ studies
Enhancing Shelf Life and Bioavailability of Vitamin D Through Encapsulation: A Comprehensive Review. Jan 2025 https://doi.org/10.1007/s11483-024-09906-x PDF behind paywall
Preparation, modelling, characterization and release profile of vitamin D3 nanoemulsion - Nov 2022 - FREE PDF
The Efficacy of Nanoemulsion-Based Delivery to Improve Vitamin D Absorption: Comparison of In Vitro and In Vivo Studies- Dec 2017 https://doi.org/10.1002/mnfr.201700836 📄 PDF via SciHub
Efficacy of Nano-Based Strategies on the Safe Delivery and Bioavailability of Vitamin D: Review -Jun 2023 https://doi.org/10.1080/87559129.2023.2225591
Desserts Enriched with a Nanoemulsion Loaded with Vitamin D3 and Omega-3 Fatty Acids for Older People - June 2024 FREE PDF
Enhancing Shelf Life and Bioavailability of Vitamin D Through Encapsulation: A Comprehensive Review - Nov. 2024 https://doi.org/10.1007/s11483-024-09906-x
Vitamin D3-Loaded Nanoemulsions as a Potential Drug Delivery System for Autistic Children: Formulation Development, Safety, and Pharmacokinetic Studies - Feb, 2023 FREE PDF
Vitamin D nanoemulsions 3.9X more bioavailable than Vitamin D micelles – Feb 2018
The Efficacy of Nanoemulsion-Based Delivery to Improve Vitamin D Absorption: Comparison of In Vitro and In Vivo Studies
Comparative Study Mol Nutr Food Res 2018 Feb;62(4). doi: 10.1002/mnfr.201700836
Alagu Selvi Kadappan 1, Chi Guo 1 2, Cansu E Gumus 3 4, Amy Bessey 1, Richard J Wood 1, David J McClements 3, Zhenhua Liu 1 5
Nanoemulsions result in more uniform response than other forms
Scope: Vitamin D (VD) is a fat-soluble vitamin that has a wide range of skeletal and non-skeletal functions. Although it can be synthesized through sun exposure and obtained from fortified foods, VD inadequacy is epidemic worldwide. Therefore innovative strategies are necessary for improving VD status. The present study examined VD absorption via nanoscale delivery systems.
Methods and results: We examine the physical characteristics and in vitro bioaccessibility of cholecalciferol (VD3 ) in nanoemulsion using a simulated gastrointestinal tract system. To evaluate the in vivo bioavailability, we orally administer three groups of mice with VD3 nanoemulsion, VD3 coarse emulsion, or vehicle nanoemulsion without VD3 , and the serum 25(OH)D3 is measured using radioactive immunoassay. The nanoemulsion-based delivery system increases the in vitro bioaccessibility by 3.94-folds (p < 0.05), as indicated by the concentration of vitamin D3 in micelles. Our animal study shows that, when compared to the vehicle group, the coarse emulsion numerically increases the serum 25(OH)D3 by 36%, whereas the nanoemulsion statistically significantly increases the serum 25(OH)D3 by 73% (p < 0.01).
Conclusion: Our findings indicate that a nanoemulsion-based delivery system is a promising approach to improve VD bioavailability, and further studies are warranted to determine its efficacy in humans.
📄 Download the SciHub PDF from Vitamin D Life
Study was cited 74 times as of Sept 2024
Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023
An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants
Journal of Orthopaedics Volume 35, January 2023, Pages 64-68 https://doi.org/10.1016/j.jor.2022.10.017
Raman Kumar Marwaha a, Manish Verma b 1, Ajit Walekar c, Rakesh Sonawane b 2, Chirag Trivedi c
Background
Nanoemulsion preparations of cholecalciferol available in the market claim to have better bioavailability than the conventional fat-soluble cholecalciferol. However, limited data are available in humans for such preparations. We, therefore, compared the relative bioavailability of two formulations of 60,000 IU cholecalciferol (nanoemulsion oral solution, water-miscible vitamin D3 [test] vs soft gelatin capsules [reference]) in healthy adult participants.
Methods
In this randomized, open-label, two-sequence, single-dose, two-way crossover study (CTRI/2018/05/013839), Indian participants aged 18–45 years received single dose of nanoemulsion and capsule formulations, under fasting conditions. Blood samples collected over 120 h were assessed to determine cholecalciferol concentrations. Pharmacokinetic parameters (area under the concentration-time curve up to 120 h [AUC0–120h], maximum observed drug concentration [Cmax], time to reach maximum drug concentration [Tmax], terminal half-life [T½el], and terminal elimination rate constant [Kel]) were estimated using baseline corrected data and analyzed using analysis of variance.
Results
Among the 24 eligible participants, the relative bioavailability of nanoemulsion was significantly higher than the capsules by 36% (p = 0.0001) based on AUC0–120h. Similarly, Cmax of the nanoemulsion was significantly higher by 43% (p = 0.0001) than that of the capsules. The intra-participant variability for AUC0–120h and Cmax were 23.22% and 26.51%, respectively. The Tmax, T½el, and Kel were comparable for both the formulations. No adverse effects were noted with either of the two formulations.
Conclusions
Nanoemulsion oral solution of cholecalciferol showed a greater bioavailability compared with soft gelatin capsules, under fasting conditions, in healthy human participants.
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Nanoemulsion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019
Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview
J. of Clinical Orthopaedics & Trauma Nov–Dec 2019, pg 1094-1096 https://doi.org/10.1016/j.jcot.2019.07.014
Raman Kumar Marwaha a, Aashima Dabas b
Vitamin D deficiency is recognized as a pandemic affecting all ages and strata of population. The endogenous cutaneous synthesis of vitamin D is insufficient to maintain normal body requirement which necessitates the need for vitamin D supplementation or food-fortification. Conventional fat-soluble preparations of vitamin D have been traditionally used for prevention and therapeutic purposes. Recent advances in technology have enabled delivery of vitamin D through nanoemulsion formulations which ensure higher absorption and drug delivery. The following review briefly discusses the issues of bioavailability of nanoemulsion preparation of vitamin D vis-a-vis conventional fat soluble preparations.
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Clipped from PDF
"...a single oral dose of 60,000 IU in healthy participants. The results showed that relative bioavailability in terms of serum levels of cholecalciferol following supplementation with nano preparation of vitamin D3 was significantly higher than fat-soluble D3 by 36%(P ¼ 0.001) based on AUC 0-120. "
Clipped from PDF
The nanoemulsions are considered superior to conventional vitamin D preparations for the following reasons:
a) It has greater therapeutic role in patients with malabsorption syndromes due to
Inflammatory bowel disease,
Celiac disease,
Short bowel syndrome,
Hepatobiliary disorders,
Pancreatic insufficiency and
Bariatric surgery who suffer from a deficiency of essential fatty acids and fat-soluble vitamins including vitamin D,
b) Better compliance as it can be taken directly or with water/juice etc.
c) Vitamin D nanoemulsions may also have also greater hepato-protective effect against high-fat diet-induced liver injury as observed in rats compared to conventional oral vitamin D preparations.
Current Update on Nanoemulsion A Review - Jan 2021
CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech
Nanoemulsions for health, food, and cosmetics
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Nanoemulsions SciHub 2020
Nanoemulsions - The rising star of antiviral therapeutics
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19+ Vitamin D Life pages with NANOEMULSION or EMULSION etc. in the title
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See also in Vitamin D Life
Inhaled Vitamin D diluted nanoemulsion
Nanoemulsion Vitamin D may be a substantially better form includes the following comparison
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