Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT

Created January 2021

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial

Journal of Alzheimer's Disease, vol. 78, no. 4, pp. 1509-1518, 2020 DOI 10.3233/JAD-200926

Tong Yanga,b, Hualou Wanga,b, Ying Xiongc, Chong Chend,e,f,g, Keran Duanh, Jingya Jiaa,b and Fei Maa,b,

Cognitive parameters having high probability of improvement (p<0.001)

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Most previous studies have found that larger increases in Vitamin D levels were needed. Why did the brain showed so many improvements with such a low dose?    More Magnesium?    Get across brain barrier better for some reason?* Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017* The Role of Vitamin D in Brain Health: A Mini Literature Review – Sept 2018* IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)* Fewer cognitive problems if more sun or Vitamin DCognitive intervention trials with Vitamin D: {category}A potential way of getting more Vitamin D into the brain* Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020* Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018 1. Cognitive category starts with the following{include}

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Vitamin D levels in blood were raised only a small amount

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Background: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial.

Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress.

Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months.

Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8 - O XO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001).

Conclusion: Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.

Tags: Cognitive Intervention