Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss

Created June 2015

The Tim Ferriss Show, Episode 12: Dr. Rhonda Patrick on Life Extension, Performance, and Much More

Search Vitamin D Life for METHYLATION 354 items as of April 2018Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 Epigenetics, vitamin D, and Multiple Sclerosis includes methylationEpigenetics of Multiple Sclerosis – March 2014 Vitamin D and the epigenome - April 2014 Health problems can persist through many generations – Epigenetics and Vitamin D Magnesium and Vitamin D category listing has items along with related searchesAll-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015 5.8 X more likely to die in 15 year followup if low vitamin D and poor methylation – July 2018 Less DNA repair if nutrient deficient (Vitamin D, Magnesium, Omega-3, Vitamin K, etc) – Ames Oct 2018

Some highlights of 78 minute Podcast

00:00:30 - Who the episode is for: nerds, biohackers, people interested in life extension, dangers and promises of supplements, and performance enhancement.
00:08:34 - Preventing micronutrient deficiencies ( magnesium, vitamin K, vitamin D, etc. ) over time cause insidious deficiency that rear their head as age related diseases later like cancer, neurodegenerative diseases, type II diabetes and more.
00:09:45 - Explanation of Rhonda's use of the term "translational research" . Applying mechanistic insights from science directly into practice where it's used in the real world.
00:11:03 - What causes micronutrient inadequacies?
00:11:40 - Clarification of definition of micronutrient inadequacy. Inadequacy is different from deficiency because symptoms may be subclinical and not observable unless you know what to look for.
00:12:30 - Magnesium is in the center of the chlorophyll molecule.
00:13:15 - Magnesium is essential for about 300 different enzymes in the body.
00:13:23 - Enter discussion of the triage theory. A theory that the body rations micronutrients to proteins and enzymes in the body for short-term, immediate survival .
00:16:30 - It makes sense to try to prevent damage (e.g. that of the insidious damage caused by micronutrient deficiency over years) than try to patch it up after the fact.
00:16:52 - Discuss of Vitamin K in nato, kimchee and vegetables. Covers pronunciation of nato!
00:17:44 - Focus on eating more green leafy vegetables chiefly instead of focusing on supplementing K2, since the K1 from green leafy vegetables convert K1 to K2. (Note: most people get sucked into minutiae instead of just addressing the most important fundamental - eat green leafy vegetables.)
00:21:50 - Minerals are required as cofactors for a lot of enzymes , because they're very small they're very similar in their structure. If you supplement too much of a given mineral and are disproportionately lacking in a mineral that is close on the periodic table then your enzymes will start to take use the wrong cofactors, which causes them to not work as well.
00:22:50 - Some studies show that the maximum amount of magnesium you can absorb from a single dose (supplementing) is something like 123mg .
00:25:22 - Supplementing context radically changes if a person is already in a diseased state.
00:30:25 - The difference between cancer initiators versus cancer promoters
00:30:57 - Begin discussion of IGF-1 (insulin-like growth factor 1).
00:41:58 - Begin "what is methylation?" (Epigenetics 101)
00:44:02 - Explanation of autophagy: the process by which cell essentials eats itself, destroying dysfunctional organelles, dysfunctional mitochondria & endoplasmic reticulum.
00:46:32 - Rhonda explains the difference between cancer initiators, which cause the initial mutation, and cancer promoters, which allow the caner cells to proliferate and reproduce.
00:48:28 - Epigenetic: epi means "on-top of". Epigenetics definition: changes in methylation/acetylation patterns (mostly) within your lifetime which influence the behavior of your genes in the context of your environment.
00:52:27 - Begin discussion of new study where the authors were able to demonstrate with an accuracy of around 96% the ability to predict someones age within 4 years by the methylation pattern of their genome alone.
SOME LINKS FROM THE EPISODE: