Many Neurological Diseases fought by Vitamin D
Vitamin D in Neurological Diseases
Int. J. Mol. Sci. 2023, 24(1), 87; https://doi.org/10.3390/ijms24010087
by Domenico Plantone 1,*ORCID,Guido Primiano 2,3ORCID,Carlo Manco 1,Sara Locci 1,Serenella Servidei 2,3ORCID andNicola De Stefano 1
1 Centre for Precision and Translational Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy
2 Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
3 Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Table of Contents
Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course of progressive neurological diseases.
In this narrative review, we summarise vitamin D chemistry, metabolism, mechanisms of action, and the recommended daily intake.
The role of vitamin D on gene transcription and the immune response is also reviewed. Finally, we discuss the scientific evidence that links low 25-hydroxyvitamin D concentrations to the onset and progression of severe neurological diseases, such as
multiple sclerosis,
Parkinson’s disease,
Alzheimer’s disease,
migraine,
diabetic neuropathy and
amyotrophic lateral sclerosis.
Completed and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed.
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