Lupus treated again by daily Vitamin D - 4,000 IU or 8,000 IU (slightly better) - RCT
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus
Cureus 17(2): e78830. doi:10.7759/cureus.78830
Oana Raluca Predescu • Florentin Ananu Vreju • Anca Emanuela Musetescu • Alesandra Florescu • Stefan Cristian Dinescu • Cristina Elena Bita • Andreea Lili Barbulescu • Paulina Lucia Ciurea
less fatigue, but little reduction is Lupus disease activity
Note: Other Lupus studies have found that the Vitamin D Receptor needs activation
by VDR activators or weekly instead of daily Vitamin D
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and various clinical symptoms, with vitamin D deficiency suggested as a contributing factor. This study aimed to evaluate the effects of vitamin D supplementation on fatigue and disease activity in SLE patients.
Methods: Patients diagnosed based on EULAR/ACR 2019 criteria were divided into three groups: no supplementation, 4000 IU, and 8000 IU of vitamin D daily for six months . Clinical assessments included serum complement levels (C3 and C4),
fatigue scores (Functional Assessment of Chronic Illness Therapy ( FACIT )
Fatigue and Fatigue Severity Scale ( FSS ), and
disease activity (Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index ( SELENA-SLEDAI ).
Results: Results showed significant increases in vitamin D levels and serum complement levels in the supplementation groups. Serum complement levels and fatigue scores improved significantly in both the 4000 IU and 8000 IU groups. Additionally, there was a slight reduction in SELENA-SLEDAI scores in the treated groups, but without statistical significance.
Conclusions: The findings suggest that vitamin D supplementation positively affects fatigue and some parameters of disease activity in SLE patients, though its overall impact on disease activity needs further investigation.
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