Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis

Created September 2018

Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake: A dose-response PRISMA meta-analysis.

Medicine (Baltimore). 2018 Sep;97(37):e12282. doi: 10.1097/MD.0000000000012282.

Wei H1, Jing H1, Wei Q1, Wei G1 [email protected], Heng Z2 [email protected]

1 Department of Radiology, the Fifth Hospital of Wuhan.

2 Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.

* Overview Lung cancer and vitamin D* Smoking reduces vitamin D - many studies Has the following items* Having enough vitamin D might allow a person to quit smoking* More tobacco cancer if lower level of vitamin D - 2013* Smokers with > 30 ng level of vitamin D had 0.43 the risk of getting tobbaco-related cancer - 2015* * Cancer - After Diagnosis category listing has items along with related searches** --- 1. # Items in both categories Lung Cancer and Meta-analysis are listed here:{category}

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The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.

The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945-1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854 , 95% CI = 0.741-0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957-0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis.

Tags: Cancer - Lung Meta-analysis