Lumbar Degenerative Disc Disease 3X more likely if poor Vitamin D Receptor

Association of rs2228570 Polymorphism of Vitamin D Receptor Gene with Lumbar Degenerative Disc Disease.

Turk Neurosurg. 2018 Mar 11. doi: 10.5137/1019-5149.JTN.22275-17.2. [Epub ahead of print]

Özdoğan S1, Yaltirik CK, Yilmaz SG, Koçak A, Isbir T.

Istanbul Training and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey.

Yes, poor backs can be due to genetics and can run in families* * Back Pain category listing has items along with related searches** * Back pain cured with vitamin D – book May 2014* Back pain extremely associated with low level of vitamin D – May 2014* Back pain reduced for 95 percent of those who took vitamin D - 2003* This file resulted in the creation of Vitamin D Life in 2010Items in both categories Back Pain and Vitamin D Receptor are listed here: {category}---* Back pain is 4th biggest global cause of disability: ages 50-69 1. Vitamin D Receptor category has the following{include}--- 1. Comments by Henry Lahore, founder of Vitamin D Life (Who used to have a lot of back pain)The Vitamin D Receptor only limits the amount of vitamin D getting to a cell, it does not stop it.If you have a poor vitamin D receptor you need more Vitamin D than others (3X?)Suspect that applying Vitamin D topically to the back might help - no dataTopical Magnesium (with DMSO) relieves tense muscles in minutes (in back and elsewhere)

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AIM:

Lumbar degenerative disc disease (LDDD) is the most common cause of lower back pain (LBP) and sciatica. The vitamin D receptor (VDR) gene, which is located on chromosome 12 (12q12-q14), was the first gene reported to be potentially related to intervertebral degenerative disc disease risks. We conducted a case-control study of a Turkish population and investigated the association between the VDR gene rs2228570 FokI polymorphism and the development of LDDD.

MATERIAL AND METHODS:

This was a prospective case-control study that included 45 patients with LDDD and 49 healthy individuals (control group). The clinical investigations of the LDDD patients consisted of neurological examinations, lumbar magnetic resonance imaging studies, visual analog scale (VAS) scores, and Oswestry Disability Index scores. The VDR gene rs2228570 FokI polymorphism was analyzed via a real-time polymerase chain reaction.

RESULTS:

We found that the individuals with the VDR GG genotype had a significantly increased risk of LDDD, while those with the AG genotype had a significantly decreased risk. In addition, the A allele may have a protective effect against LDDD in the Turkish population. Moreover, the VAS pain results showed that the GG genotype had a significantly higher score than the others.

CONCLUSION:

Our results suggested that the VDR rs2228570 AG genotype was at a decreased risk and the GG genotype was at an increased risk of LDDD in the Turkish population. Since genetic polymorphisms often show ethnic differences, further functional studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.

PMID: 29569696 DOI: 10.5137/1019-5149.JTN.22275-17.2