Low Level Laser therapy and photobiomodulation proven to help health for many years

Created May 2020

Sunlight and Health: Shifting the Focus From Vitamin D3 to Photobiomodulation by Red and Near-Infrared Light

Review Ageing Res Rev. 2020 May 25;101089. doi: 10.1016/j.arr.2020.101089

Vladimir Heiskanen 1 [email protected], Morgan Pfiffner 2, Timo Partonen 3

A decade of very positive personal experience with Low Level Laser TherapyThe founder of Vitamin D Life designed and bullt an LLLT for his wife's lymphedema which resulted from Breast Cancer treatments.My LLLT was designed to shine flashing 902 nanometer infrared light as deep as 2 inches into the body,An LLLT book from Russia indicated that the on/off flashing far more important than just the intensity of light.My LLLT flashes the light 100,000 times per secondSince 2009 (before starting Vitamin D Life) it worked well for lymphedema as well as many other health problems that are near to the surface of the skin.LLLT treatment has more variables than Vitamin DI expect it will take at least another decade for the medical profession to come to use it* Frequency of light* Perhaps multiple frequencies could be used concurrently* Intensity of Light* Intensity modulation of light while it is on* Use of pulsed light to get far deeper into the body* Pulsing of light to improve benefit over that of just intensity * Duty cycle might be important* varying the pusle rate might be important - the cells "get used" toa constant rate * When the treatment is given (appears that just before bedtime is great)* How many different sites on the body is treated at a session * It appears that too many sites results in less healing focus by the body--- 1. Vitamin D Life pages with LOW LEVEL LASER in titleThis list is automatcially updated{LIST()}

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Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast body of randomized controlled trials (RCTs) and Mendelian randomization studies have failed to confirm any major health benefits from vitamin D supplementation. In this review, we present tentative evidence showing that red and near-infrared light, both being present in sunlight, could explain the associations between sunlight exposure and better health status. Body irradiation with red and near-infrared light, usually termed as photobiomodulation (PBM), has demonstrated beneficial effects in animal models of chronic diseases. Beyond this, preliminary evidence from RCTs suggest potential clinical benefit from PBM for chronic diseases. PBM is currently being investigated in many pre-registered clinical trials, results of which will eventually clarify the role of red and near-infrared light in the prevention and treatment of common age-related chronic diseases.

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The exact mechanisms for these effects are not well known, though preliminary evidence suggests

possible roles for mitochondrial cytochrome c oxidase and photolabile sources of nitric oxide

(Serrage et al., 2019). The existence of mitochondria-related mechanism is supported by studies

reporting photobiomodulation-induced changes in ATP levels, mitochondrial membrane potential

(ΔΨm), cytochrome c oxidase activity, oxygen consumption and activity of SIRT1/PGC1α pathway,

as well as protection of mitochondria against toxins such as potassium cyanide and tetrodotoxin

(Hamblin, 2018; Wong-Riley et al., 2005; Zhang et al., 2020).

Currently, the scientific literature concerning PBM encompasses more than 4,500 scientific articles,

including more than 1500 animal trials and 700 randomized clinical trials. The publication rate of PBM

research has increased rapidly during the 21st century, and the current publication rate is

approximately 500 new articles annually (Figure 1)

The overview is based on a personal database of approximately 4700 scientific articles related to PBM,

compiled by manual literature search (http://www.bitly.com/PBM-database; Accessed on 3 March 2020

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