Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng)

Created July 2017

Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients

Nutrients 2017, 9(8), 799; doi:10.3390/nu9080799

This is one of the few studies still using Vitamin D2 (D3 is not available in Thailand)Vitamin D2 provides about 30% less response than D3 with daily dosingVitamin D2 provides about 50% less response than D3 with weekly dosingThis study would have gotten far more than 57% of participants > 30 ng if they had used Vitamin D3 1. See also Vitamin D LifeVitamin D, Magnesium, Boron, and Omega-3 all decrease OA – I use all four and have essentially eliminated my knee osteoarthritis – Henry Lahore, founder of Vitamin D Life* I needed more than Vitamin D to treat my knee osteoarthritis* Overview Osteoarthritis and Vitamin D* Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017* Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013* Knee osteoarthritis strongly associated with low Boron – 2015* Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015* Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015* Knee pain in seniors predicted by low vitamin D 5 years before – Feb 2014* Overview Magnesium and vitamin D* Overview Vitamin D3 not D2* Low vitamin D in yet another sunny country-Thailand - March 2015

📄 Download the PDF from Vitamin D Life

Pacharee Manoy 1, Pongsak Yuktanandana 2, Aree Tanavalee 2, Wilai Anomasiri 3, Srihatach Ngarmukos 2, Thanathep Tanpowpong 2 and Sittisak Honsawek 2,3, * OrcID

  • 1 Program in Medical Sciences, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand

  • 2 Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand

  • 3 Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand

Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D2 supplementation on muscle strength and physical performance in knee OA patients;

Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D2 (ergocalciferol) per week for six months. Body composition, muscle strength, physical performance, serum 25(OH)D level, leptin, interlukin-6 (IL-6), parathyroid hormone (PTH), protein carbonyl, and metabolic profile were analyzed;

Results: Baseline mean serum 25(OH)D levels in knee OA patients was 20.73 ng/mL. Regarding baseline vitamin D status, 58.90% of patients had vitamin D insufficiency, and 41.10% had vitamin D deficiency. After vitamin D2 supplementation for six months, mean serum 25(OH)D level was 32.14 ng/mL. For post-supplementation vitamin D status, 57.10% of patients had vitamin D sufficiency and 42.90% had vitamin D insufficiency. From baseline to six months, there was a significant increase in mean serum 25(OH)D level (p < 0.001), while mean LDL cholesterol (p = 0.001), protein carbonyl (p = 0.04), and PTH (p = 0.005) all significantly decreased. Patient quality of life (SF-12) and pain (visual analog scale, VAS) both improved significantly from baseline to the six-month time point (p = 0.005 and p = 0.002, respectively). Knee OA patients demonstrated significant improvement grip strength and physical performance measurements after vitamin D2 supplementation (p < 0.05);

Conclusions: Vitamin D2 supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients.

Tags: Osteoarthritis