Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT
Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial
Global Journal of Health Science; Vol. 9, No. 3; 2017 ISSN 1916-9736 E-ISSN 1916-9744 Published by Canadian Center of Science and Education
Mansoureh Samimi1, Fatemeh Foroozanfard1, Farzaneh Amini1 & Mojtaba Sehat2
Department of Obstetric and Gynecology, Kashan University of Medical Sciences, Kashan, IR Iran
Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
Correspondence: Farzaneh Amini, Department of Obstetric and Gynecology Shabih-Khani Hospital, Shahid Beheshti Street, Kashan, Isfahan, Iran. Tel: 98-31-5554-0021. E-mail: [email protected]
nanograms | Miscarriages || Vitamin D | 400 IU | 13 | 13% || Placebo | 0 IU | 11 | 34% |See also Vitamin D LifeIt is rare to find a benefit with just 400 IU of vitamin DNote: Vitamin D levels of women in the Middle East are VERY low, so even 400 IU can help* Vitamin D given to ALL high schools girls in Iran – 75 percent deficiency dropped to 6 percent – April 2016* Saudi females twice as likely to be vitamin D deficient as males (cloth) – July 2015* Overview Middle East and vitamin D* Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015* Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016* WHO still says mistakenly says NO vitamin D during pregnancy, and only 200 IU after* Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016* Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017* Second miscarriage associated with low vitamin D – review June 2018Pregnancy category starts with{include}
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Note: there are several mistakes in the following abstract which are clarified in the PDF text.
Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA).
Methods: A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation.
Results: The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2).
Conclusions: Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.