Inflammation associated with Cancer reduced by Vitamin D – meta-analysis

Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials

Clin Nutr. 2023 May 17;S0261-5614(23)00151-6. doi: 10.1016/j.clnu.2023.05.009

Tafirenyika Gwenzi 1, Anna Zhu 2, Petra Schrotz-King 3, Ben Schöttker 4, Michael Hoffmeister 5, Hermann Brenner 6

Background & aims: Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions.

Methods: We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups.

Results: Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: -1.65 [-3.07; -0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: -0.83, [-1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: -0.09, [-0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: -0.00, [-0.50; 0.49]).

Conclusion: Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response.

Prospero registration number: CRD42022295694.

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Note: Many of the trials used too little vitamin D to be of any possible benefit

4+ Vitamin D Life Inflammation pages with CANCER in the title

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Vitamin D Life – Cancer category contains

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Vitamin D Life – Cancer increases if poor Vitamin D Receptor (not mentioned in study on this page)

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